Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Vicente Jover CerdáMaría Luz de la Sen Fernández

Abstract

Polyethylene glycols (PEGs) and their derivatives are non-ionic polymers of ethylene oxide commercially available with numerous synonyms, such as macrogol, oxyethylene polymer, and laureth-9. Although these polymers are usually safe, mild to life-threatening immediate-type hypersensitivity reactions have been reported. Nevertheless, awareness about their allergic potential is minimal due to the non-standardization of their nomenclature. We present the case of a 29-years-old woman who developed several local and systemic type I hypersensitivity reactions including a severe anaphylactic reaction to different pharmacologic and cosmetic products whose excipients included PEG. Prick tests and basophil activation tests were performed to several pharmacological and cosmetic products, but only those containing PEGs and their derivatives were positive. The patient was diagnosed with immediate hypersensitivity IgE-mediated to PEGs and its derivatives. Standardization of the terminology used to describe the presence of PEGs in products would help patients to identify them clearly and unequivocally and thus avoid the development of hypersensitivity reactions. It is also recommended studying PEG allergy in reactions to products containing P...Continue Reading

References

Jan 15, 2009·Angewandte Chemie·Alister C FrenchBenjamin G Davis
May 20, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Wenande, L H Garvey
Dec 4, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Elaine Y L AuEric Chan

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Citations

Jan 5, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Maria A Bruusgaard-MouritsenLene H Garvey
Mar 20, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Maria Luisa CaballeroCosby A Stone
Apr 16, 2021·The Journal of Allergy and Clinical Immunology·Kimberly A RismaJoshua D Milner
May 1, 2021·Pharmaceutics·Alex N FrickensteinLacey R McNally
May 2, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Viktorija Erdeljic Turk
Jun 7, 2021·Current Opinion in Allergy and Clinical Immunology·Lennart NilssonMaria C Jenmalm
Aug 3, 2021·Experimental and Therapeutic Medicine·Irena PinteaDiana Deleanu
Oct 29, 2021·Internal Medicine·Shinichi MatsuzakiMasashi Arai
Sep 10, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Gianfranco CalogiuriAngelo Vacca

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