Immediate Oral Refeeding in Patients With Mild and Moderate Acute Pancreatitis: A Multicenter, Randomized Controlled Trial (PADI trial).

Annals of Surgery
Elena Ramírez-MaldonadoRosa Jorba

Abstract

To establish the optimal time to start oral refeeding in mild and moderate acute pancreatitis (AP) to reduce hospital length-of-stay (LOS) and complications. Oral diet is essential in mild and moderate AP. The greatest benefits are obtained if refeeding starts early; however, the definition of "early" remains controversial. This multicenter, randomized, controlled trial (NCT03829085) included patients with a diagnosis of mild or moderate AP admitted consecutively to 4 hospitals from 2017 to 2019. Patients were randomized into 2 treatment groups: immediate oral refeeding (IORF) and conventional oral refeeding (CORF). The IORF group (low-fat-solid diet initiated immediately after hospital admission) was compared to CORF group (progressive oral diet was restarted when clinical and laboratory parameters had improved) in terms of LOS (primary endpoint), pain relapse, diet intolerance, complications, and, hospital costs. One hundred and thirty one patients were included for randomization. The mean LOS for the IORF and CORF groups was 3.4 (SD ± 1.7) and 8.8 (SD ± 7.9) days, respectively (P < 0.001). In the CORF group alone, pain relapse rate was 16%. There were fewer complications (8% vs 26%) and health costs were twice as low, with a...Continue Reading

References

Jun 19, 2007·The American Journal of Gastroenterology·Maxim S PetrovHein G Gooszen
Jul 7, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian C JacobsonPeter A Banks
Aug 28, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gunilla E EckerwallRoland G Andersson
Nov 20, 2008·The British Journal of Nutrition·Maxim S PetrovAntonina F Uchugina
Nov 1, 2011·International Journal of Surgery·David MoherUNKNOWN CONSORT
Nov 11, 2011·World Journal of Gastroenterology : WJG·Wen-Bo MengXiao-Liang Zhu
Jun 28, 2012·Annals of Surgery·E Patchen DellingerUNKNOWN Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA)
Oct 27, 2012·Gut·Peter A BanksUNKNOWN Acute Pancreatitis Classification Working Group
Dec 15, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Nagarajan RajkumarVikram Kate
Jan 24, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Maxim S PetrovJohn A Windsor
Jul 31, 2013·The American Journal of Gastroenterology·Scott TennerUNKNOWN American College of Gastroenterology
May 24, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J Lariño-NoiaJ E Domínguez-Muñoz
Oct 22, 2014·The British Journal of Nutrition·Deirdre M NallyPaul Ridgway
Nov 20, 2014·The New England Journal of Medicine·Olaf J BakkerUNKNOWN Dutch Pancreatitis Study Group
Dec 5, 2014·World Journal of Gastroenterology : WJG·Attila Oláh, Laszlo Romics
Apr 24, 2015·Journal of Hepato-biliary-pancreatic Sciences·Shuji IsajiToshifumi Gabata
Aug 21, 2015·Expert Review of Gastroenterology & Hepatology·Melody G BevanMaxim S Petrov
Dec 2, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·J A GreenbergR S McLeod
Jan 20, 2016·Critical Care Medicine·Felix Zubia-OlaskoagaUNKNOWN in representation of the Epidemiology of Acute Pancreatitis in Intensive Care Medicine Study Group
Jan 30, 2016·Expert Review of Gastroenterology & Hepatology·Piet J LodewijkxUNKNOWN Dutch Pancreatitis Study Group
Mar 24, 2016·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Joshua A GreenbergRobin S McLeod
Apr 25, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·D StimacS Milic
Jun 28, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Melody G BevanMaxim S Petrov
Oct 5, 2016·Scandinavian Journal of Gastroenterology·Tim RagnarssonBodil Andersson
Apr 15, 2017·United European Gastroenterology Journal·Masayasu HoribeTakanori Kanai
May 16, 2017·Annals of Internal Medicine·Valerie M VaughnVineet Chopra
Sep 6, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Meng JinHong Yang
Feb 6, 2018·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Andrea PárniczkyPéter Hegyi
Feb 8, 2018·Gastroenterology·Seth D CrockettUNKNOWN American Gastroenterological Association Institute Clinical Guidelines Committee
Feb 8, 2018·Gastroenterology Clinics of North America·Kristen M RobertsLuis F Lara
Aug 29, 2018·Gastroenterología y hepatología·Francisco Valverde-LópezEduardo Redondo-Cerezo
Nov 30, 2018·Nature Reviews. Gastroenterology & Hepatology·Maxim S Petrov, Dhiraj Yadav

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT03829085

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.