PMID: 3772158Nov 1, 1986Paper

Immediate pigment darkening phenomenon. A reevaluation of its mechanisms

The Journal of Investigative Dermatology
H HönigsmannK Wolff

Abstract

Proposed mechanisms of immediate pigment darkening (IPD) are controversial. They include photooxidation of "premelanin," changes in the distribution pattern of microfilaments and microtubules, movement of melanosomes to melanocyte dendrites, increased transfer of melanosomes to keratinocytes, and changes in the melanosome distribution pattern in keratinocytes. We investigated the following aspects of IPD: production of IPD by UVA under physiologic and nonphysiologic conditions in fullthickness skin and epidermal sheets; reversibility of IPD in vitro after in vivo and in vitro production; blocking of IPD by disruption of the microfibrillar or microtubular system in vitro; alterations of the cytoskeleton of melanocytes; the melanosome distribution pattern in melanocytes and keratinocytes. The results were as follows: IPD could be elicited in vitro in full-thickness skin and in epidermal sheets. Its production was temperature independent (0 degrees-37 degrees C) and was not inhibited by repeated freezing and thawing, or by formalin fixation. IPD was reversible in vitro under tissue culture conditions but only in viable skin. IPD could not be blocked by substances that disrupt the microfibrillar or microtubular system (cytochalasin...Continue Reading

References

May 1, 1979·The Journal of Investigative Dermatology·K H Kaidbey, A M Kligman
Nov 1, 1985·The Journal of Investigative Dermatology·G BlackR W Gange
Mar 11, 1968·Archives of Biochemistry and Biophysics·M A Pathak, K Stratton
Dec 1, 1972·The Journal of Investigative Dermatology·I WillisJ Epstein
Aug 1, 1972·The Journal of Investigative Dermatology·M A Wikswo, G Szabo
Jan 15, 1971·Science·N K WessellsK Yamada

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Citations

Nov 16, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jean-Paul Ortonne, Thomas Schwarz
Jun 12, 2010·Health Physics·UNKNOWN International Commission on Non-Ionizing Radiation Protection
Jun 30, 2015·PloS One·Manpreet RandhawaEduardo Ruvolo
Mar 1, 1991·Physics in Medicine and Biology·B L Diffey
Oct 1, 1993·Journal of Cellular Physiology·N S DissanayakeR S Mason
Mar 1, 1993·Photochemistry and Photobiology·C IrwinK Kaidbey
Jun 18, 2019·Photodermatology, Photoimmunology & Photomedicine·Indermeet KohliNikiforos Kollias
Mar 1, 1991·Pigment Cell Research·J M Pawelek
Nov 30, 1999·Photodermatology, Photoimmunology & Photomedicine·N Kollias, J L Bykowski
Jan 26, 2007·Pigment Cell Research·Yoshinori MiyamuraVincent J Hearing
Feb 20, 2009·Pigment Cell & Melanoma Research·Sergio G CoelhoJanusz Z Beer
Dec 24, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alois W SchmalwieserBrian Diffey
Jul 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hawasatu DumbuyaElena Oancea
Jul 31, 2002·Photodermatology, Photoimmunology & Photomedicine·Herbert Hönigsmann
Dec 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Johan MoanAsta Juzeniene
Sep 13, 2018·International Journal of Molecular Sciences·Sandra Del BinoFrançoise Bernerd
Aug 14, 2009·The Journal of Investigative Dermatology. Symposium Proceedings·Sergio G CoelhoVincent J Hearing
Jul 3, 2021·International Journal of Molecular Sciences·Barbara JacczakEwa Totoń
Jul 28, 2021·International Journal of Cosmetic Science·Juanjuan ChenJie Qiu
Aug 1, 1988·Journal of the American Academy of Dermatology·J L Bolognia, J M Pawelek
Jun 2, 2009·Journal of Photochemistry and Photobiology. B, Biology·Asta JuzenieneJohan Moan

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