Immediate postoperative radiotherapy or "watch and wait" in the management of adult low-grade glioma?

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Rolf-Dieter KortmannMichael Bamberg

Abstract

The EORTC Trial 22845 on the role of immediate postoperative radiotherapy in patients with supratentorial lowgrade glioma revealed an advantage of immediate postoperative radiotherapy for progression-free survival, but not for overall survival. It is still an open question in which clinical setting immediate radiotherapy should be considered and whether chemotherapy may become a useful alternative. Reports in the literature spanning 60 years of radiation therapy were reviewed with respect to timing of radiotherapy, prognostic factors, dose prescriptions, modern treatment techniques, and late effects. Data on chemotherapy were also reviewed. Based on these data, the role of immediate postoperative radiotherapy or chemotherapy in adult low-grade glioma is presented. Radiotherapy is able to control symptoms in up to 80% of cases. Malignant transformation occurs in 36-86% of cases upon progressive disease. Long-term median survival crucially depends on prognostic factors and ranges between 12 months and 10 years. Radiotherapy does not cause neurocognitive deficits, provided that modern treatment techniques and moderate dose prescriptions are used. Recent series with small patient numbers indicate that chemotherapy using PCV or temo...Continue Reading

Citations

Mar 29, 2006·Current Oncology Reports·Paul D Brown
Feb 9, 2012·Chinese Journal of Cancer·Wei-Ying YueZhong-Ping Chen
Nov 20, 2014·Brain Tumor Research and Treatment·Hyun Joo BaekMoon Sun Park
Dec 21, 2007·Brain Tumor Pathology·Yoshifumi TsuboiShunro Endo
Oct 19, 2017·World Journal of Surgical Oncology·Ji ZhangShi-Yin Xiao

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