Jan 1, 1989

Immediate results of the use of prospidin in a cyanoacrylate glue compound in cancer of the esophagus

Sovetskaia meditsina
V I ChissovM M Akhmetov

Abstract

Antitumor efficacy of a medical adhesive MK-8-based polymer drug composition with prospidin has been studied in 49 Wistar rats, and the kinetics of the drug elimination has been followed up in 112 rats. The findings evidence a prolongation of a relapse-free period and a longer survival of the animals. Clinical trials of the composition have been carried out. Of the 70 patients with esophageal carcinomas 52 ones had local disseminated forms, conforming to T4P3-4 indices. Application of the adhesive composition has not increased the rate of postoperative complications and in some cases considerably prolonged the life span of patients after palliative surgery.

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Mentioned in this Paper

MK-2 glue
Piperazines
August Rats
Esophageal Diseases
Adenoid Cystic Carcinoma
Cyanoacrylates
Prospidium Chloride
Sarcoma, Jensen
Drug Evaluation
Squamous Cell Carcinoma

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