Immersed AC electrospray (iACE) for monodispersed aqueous droplet generation

Biomicrofluidics
Zehao PanHsueh-Chia Chang

Abstract

We report a new immersed alternating current (AC) electrospray droplet generation method that can generate monodispersed water-in-oil droplets, with diameters ranging from 5 μm to 150 μm, in a stationary oil phase. This method offers high through-put, easy size tuning, and droplets with a viscous aqueous phase at high ionic strengths (raw physiological samples). Yet, it does not require coordinated flows of the dispersed/continuous phases or even a microfluidic chip. The design relies on a small constant back pressure (less than 0.1 atm) to drive the water phase through a nozzle (glass micropipette) and a non-isotropic AC electric Maxwell pressure to eject it into the oil phase. Undesirable field-induced discharge and nanojet formation at the tip are suppressed with a biocompatible polymer, polyethylene oxide. Its viscoelastic property favors the monodispersed dripping mechanism, with a distinct neck forming at the capillary tip before pinch-off, such that the tip dimension is the only controlling length scale. Consecutive droplets are connected by a whipping filament that disperses the drops away from the high-field nozzle to prevent electro-coalescence. A scaling theory is developed to correlate the droplet size with the appl...Continue Reading

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Citations

Oct 22, 2020·Micromachines·Muhammad Salman AbbasiJinkee Lee
Jan 16, 2021·Physical Review Letters·Zehao PanHoward A Stone
May 6, 2021·Biomaterials Science·Zehao PanDonny Hanjaya-Putra

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