Immersion before dry simulated dive reduces cardiomyocyte function and increases mortality after decompression

Journal of Applied Physiology
Svein Erik GaustadUlrik Wisløff

Abstract

Diving and decompression performed under immersed conditions have been shown to reduce cardiac function. The mechanisms for these changes are not known. The effect of immersion before a simulated hyperbaric dive on cardiomyocyte function was studied. Twenty-three rats were assigned to four groups: control, 1 h thermoneutral immersion, dry dive, and 1 h thermoneutral immersion before a dive (preimmersion dive). Rats exposed to a dive were compressed to 700 kPa, maintained for 45 min breathing air, and decompressed linearly to the surface at a rate of 50 kPa/min. Postdive, the animals were anesthetized and the right ventricle insonated for bubble detection using ultrasound. Isolation of cardiomyocytes from the left ventricle was performed and studied using an inverted fluorescence microscope with video-based sarcomere spacing. Compared with a dry dive, preimmersion dive significantly increased bubble production and decreased the survival time (bubble grade 1 vs. 5, and survival time 60 vs. 17 min, respectively). Preimmersion dive lead to 18% decreased cardiomyocyte shortening, 20% slower diastolic relengthening, and 22% higher calcium amplitudes compared with controls. The protein levels of the sarco-endoplasmic reticulum calcium...Continue Reading

References

May 18, 1978·Pflügers Archiv : European journal of physiology·W D RischO H Gauer
Sep 1, 1990·Journal of Applied Physiology·R G EckenhoffG Carrod
Jan 1, 1989·American Journal of Nephrology·M EpsteinR Loutzenhiser
Oct 1, 1969·Journal of Applied Physiology·S K HongH Rahn
Dec 1, 2004·Medicine and Science in Sports and Exercise·Katharina Meyer, Jörn Bücking
May 11, 2006·Chest·Alain BoussugesDaniel Carturan
Aug 5, 2006·Medicine and Science in Sports and Exercise·Zeljko DujićAlf O Brubakk
Dec 25, 2007·Exercise and Sport Sciences Reviews·Zelijko DujicAlf O Brubakk
Nov 28, 2008·Journal of Applied Physiology·D R Pendergast, C E G Lundgren
Mar 20, 2009·Journal of Sports Sciences·Alain BoussugesClaude Robinet

❮ Previous
Next ❯

Citations

Jan 31, 2020·Frontiers in Physiology·Svein E GaustadTorkjel Tveita

❮ Previous
Next ❯

Related Concepts