Immersion of the hand in ice water releases adrenergic vasoconstrictor tone in the ipsilateral temple

Autonomic Neuroscience : Basic & Clinical
Peter D Drummond

Abstract

Immersion of the hand in painfully cold water induces cutaneous vasodilatation in the temples, more so ipsilaterally than contralaterally. To investigate the mechanism of this response, guanethidine or saline was administered by transcutaneous iontophoresis to a recording site in the temple of ten participants before they immersed one of their hands in ice water. Guanethidine displaces noradrenaline from sympathetic nerve terminals and inhibits sympathetic noradrenergic neurotransmission. Therefore, it was hypothesized that guanethidine pre-treatment would block vasodilatation mediated by release of sympathetic vasoconstrictor tone in cutaneous vessels in the temple. During hand immersion, increases in the amplitude of the pulse waveform detected by laser Doppler flowmetry were greater in the ipsilateral than contralateral temple (86% vs. 34% above baseline, p<0.05), and pre-treatment with guanethidine prevented this asymmetric response (ipsilateral response 21% above baseline and contralateral response 32%, difference not significant). Guanethidine also inhibited ipsilateral increases in cutaneous blood flow during hand immersion in responsive participants. These findings suggest that limb pain inhibited ipsilateral adrenergic...Continue Reading

References

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Nov 9, 2005·Trends in Cognitive Sciences·A D Bud Craig

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Citations

Oct 16, 2012·European Journal of Applied Physiology·Hideaki KashimaNaoyuki Hayashi
Oct 12, 2012·PloS One·Olivia PucciOtto Appenzeller
Aug 14, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Peter D Drummond
Feb 24, 2009·Archives of Oral Biology·Silvestro RoattaMagda Passatore
Nov 13, 2007·Medical Hypotheses·Nikolai A Shevchuk
Sep 6, 2011·Autonomic Neuroscience : Basic & Clinical·Peter D Drummond, Cheryl Chung
Jun 14, 2019·Frontiers in Neuroscience·Morry SilbersteinMary P Galea

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