Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity

European Journal of Pharmacology
R D PorsoltM Jalfre

Abstract

Rats were forced to swim in a restricted space will rapidly cease apparent attempts to escape and adopt a characteristic posture which we have termed "immobility". We show in previous experiments that immobility was reduced by a variety of antidepressant agents and thus suggested that the method could serve as a screening model for antidepressants. The present experiments showed that immobility was reduced by drugs which increase central dopaminergic and alpha-adrenergic activity but was less affected by drugs which act mainly on central serotonin. Conversely, immobility could be increased by drugs which diminish central catecholamine activity but not by drugs which inhibit central serotonin. It was concluded that immobility depended primarily on the activity of central catecholamines but that caution was required before ascribing immobility exclusively to activity within a single system.

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Citations

Apr 5, 2002·Journal of Neuroscience Research·Mariko YamanoHiroko Ohki-Hamazaki
Jan 1, 1984·Psychopharmacology·P Willner
Jan 1, 1985·Psychopharmacology·S K Kulkarni, A K Mehta
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Dec 21, 2004·Psychopharmacology·Benoit Petit-DemouliereMichel Bourin
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Jan 27, 1984·European Journal of Pharmacology·T NagataniR Kodaira

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