Immobilization of enzymes on slowly soluble carriers

Journal of Biomedical Materials Research
V P TorchilinE I Chazov

Abstract

The preparation and some properties of microspheres composed of oxidized polysaccharides and some vinyl polymers are described. The microspheres contain immobilized enzyme and can be slowly solubilized in water solutions, thereby releasing active a enzyme into the surrounding medium. The kinetic characteristics of the immobilized enzyme bound with a fragment of matrix after complete solubilization are unchanged, but the enzyme exhibits high thermostability. These preparations could have a wide range of medical applications, e.g., to form a drug "depot" directly in an affected organ.

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Citations

May 1, 1977·Journal of Biomedical Materials Research·A M RijkeS McCoy
Oct 29, 2008·Pharmaceutical Research·Eric A SimoneVladimir R Muzykantov
Mar 6, 2003·Journal of Colloid and Interface Science·Dhruba Jyoti BharaliAmarnath Maitra
Oct 6, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·R Mehvar
Nov 26, 1999·Journal of Biomaterials Science. Polymer Edition·G GiammonaG Spadaro
Jan 26, 2011·Drug Discovery Today·Jagat R KanwarRupinder K Kanwar
Sep 24, 2008·International Journal of Pharmaceutics·Fiona Ní Chearúil, Owen I Corrigan
Oct 24, 2007·Biomaterials·Thomas D DziublaVladimir R Muzykantov
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Thomas D DziublaVladimir R Muzykantov
Jan 1, 1987·Annals of the New York Academy of Sciences·V P TorchilinA V Mazaev
Aug 22, 2006·International Journal of Pharmaceutics·Surendra NimeshRamesh Chandra
Jul 1, 1995·Bioconjugate Chemistry·W R Gombotz, D K Pettit
Jan 1, 1979·Biomaterials, Medical Devices, and Artificial Organs·M SinghS K Guha
Oct 25, 2016·ChemMedChem·Søren B van WitteloostuijnKnud J Jensen
Sep 1, 1981·Journal of Biomedical Materials Research·M SinghM M Guha
Apr 1, 1985·Journal of Biomedical Materials Research·V P TorchilinV N Smirnov

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