Immobilization stress-induced increase in plasma catecholamine levels is inhibited by a prolactoliberin (salsolinol) administration

Annals of the New York Academy of Sciences
I BodnárR Kvetnansky

Abstract

Catecholamines (CAs) are significantly involved in the regulation of homeostasis of the organism at rest and especially during stressful situations. Stress induces increases in plasma CA (epinephrine and norepinephrine) levels and prolactin (PRL) release from the adenopituitary. We have recently observed that salsolinol, which is produced by the neuro-intermediate lobe of the pituitary gland and by the hypothalamus, can selectively release PRL. Salsolinol is therefore considered to be a putative endogenous PRL-releasing factor. Based on the similarity of CA and PRL responses to stressors, we investigated whether salsolinol plays a role in the regulation of plasma CA levels at rest and of CA release induced by immobilization stress (IMO). Salsolinol did not affect CA baseline levels; however, it did inhibit IMO-induced CA release. Thus, the present study shows for the first time that salsolinol is not only a PRL-releasing factor but is also a potent inhibitor of stress-induced release of epinephrine and norepinephrine.

References

Nov 28, 2001·Journal of Neuroendocrinology·B E TóthG M Nagy
Nov 21, 2002·Neurochemistry International·Krisztián Gy HomicskóGyörgy M Nagy

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Citations

Jun 16, 2010·Psychoneuroendocrinology·John S StraussUNKNOWN International Consortium for Childhood-Onset Mood Disorders
Jan 11, 2016·Journal of Neuroendocrinology·Konrad GórskiTomasz Misztal
Oct 28, 2004·Autonomic Neuroscience : Basic & Clinical·Boris MravecRichard Kvetnansky
Aug 2, 2011·Neuroscience and Biobehavioral Reviews·Lucía HipólitoAna Polache
Oct 3, 2013·Neurochemistry International·Gabrielle D BriggsPhillip W Dickson
Dec 30, 2014·Neurotoxicity Research·Edyta MożdżeńLucyna Antkiewicz-Michaluk
May 3, 2011·Reproductive Medicine and Biology·Márk OláhGyörgy M Nagy
Oct 25, 2017·Neurotoxicity Research·Magdalena Kurnik-ŁuckaKrzysztof Gil
Mar 14, 2021·Physiology & Behavior·Wataru NishimuraYasuko Noda

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