PMID: 6397076Nov 15, 1984Paper

Immobilized glycoconjugates for cell recognition studies

Analytical Biochemistry
R L Schnaar

Abstract

Specific cell-cell recognition and adhesion may involve cell surface glycoconjugates on one cell binding the complementary carbohydrate receptors on an apposing cell surface. Such interactions have been modeled by immobilizing simple synthetic glycosides, glycoproteins, glycosaminoglycans, and glycolipids on otherwise inert plastic surfaces and incubating them with intact cells. Using this approach, the ability of several cell types to recognize specific carbohydrates has been demonstrated. This carbohydrate-directed cell adhesion may depend on cell surface carbohydrate receptors which mediate both the initial specific adhesion and complex postrecognition cellular responses. While the relationship of the cell adhesion demonstrated here to cell-cell recognition in vivo has yet to be determined, this well-controlled biochemical approach may reveal new information on the way in which cells analyze and respond to their immediate external environment.

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Citations

Apr 1, 1991·Journal of Cellular Physiology·A A BogdanovV P Torchilin
Jul 1, 1990·Developmental Biology·B K BrandleyR L Schnaar
Mar 7, 1991·Biochimica Et Biophysica Acta·H J Gabius
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shaodong ZhangVirgil Percec
Dec 1, 1986·Biotechnology Progress·B S LiangH Y Wang
Jul 1, 1989·Journal of Bioluminescence and Chemiluminescence·L J BlumP R Coulet
Jul 8, 1994·Journal of Chromatography. a·A A FarooquiL A Horrocks
Jan 1, 1988·Clinical Microbiology Reviews·H D Isenberg
Dec 1, 1985·Analytical Biochemistry·R L SchnaarB K Brandley

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