Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies

Journal of Biomedical Materials Research. Part a
Michael J MitchellMichael R King

Abstract

The metastatic spread of tumor cells from the primary site to anatomically distant organs leads to a poor patient prognosis. Increasing evidence has linked adhesive interactions between circulating tumor cells (CTCs) and endothelial cells to metastatic dissemination. Microscale biomimetic flow devices hold promise as a diagnostic tool to isolate CTCs and develop metastatic therapies, utilizing E-selectin (ES) to trigger the initial rolling adhesion of tumor cells under flow. To trigger firm adhesion and capture under flow, such devices also typically require antibodies against biomarkers thought to be expressed on CTCs. This approach is challenged by the fact that CTCs are now known to exhibit heterogeneous expression of conventional biomarkers. Here, we describe surfactant-nanotube complexes to enhance ES-mediated capture and isolation of tumor cells without the use of capture antibodies. While the majority of tumor cells exhibited weaker rolling adhesion on halloysite nanotubes (HNT) coated with ES, HNT functionalization with the sodium dodecanoate (NaL) surfactant induced a switch to firm cellular adhesion under flow. Conversely, surfactant-nanotube complexes significantly reduced the number of primary human leukocytes captu...Continue Reading

References

Dec 1, 1993·The Journal of Clinical Investigation·O AbbassiC W Smith
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y S ChangL L Munn
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 18, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Michael B Kim, Ingrid H Sarelius
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Dec 2, 2005·Clinical & Experimental Metastasis·Jennifer J RahnJudith C Hugh
May 17, 2007·The Review of Scientific Instruments·I HorcasA M Baro
May 3, 2008·Seminars in Cancer Biology·Naoki Itano, Koji Kimata
Aug 21, 2008·International Journal of Cancer. Journal International Du Cancer·Sabine RiethdorfKlaus Pantel
Feb 12, 2009·ACS Nano·Yuri M LvovRonald R Price
May 12, 2009·International Journal of Cancer. Journal International Du Cancer·Braedon McDonaldLorenzo E Ferri
Jan 15, 2010·Current Opinion in Genetics & Development·Shyamala Maheswaran, Daniel A Haber
Jun 19, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew D Hughes, Michael R King
Jul 31, 2010·Journal of Surgical Oncology·Tessa M van GinhovenRon W F de Bruin
Feb 1, 2011·Blood Cells, Molecules & Diseases·Carissa J Ball, Michael R King
Feb 9, 2011·The Journal of Cell Biology·Min YuDaniel A Haber
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Dec 14, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Andrew D Hughes, Michael R King
Feb 22, 2012·Clinical Chemistry·Andrew D HughesMichael R King
Mar 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael J MitchellMichael R King
Jun 27, 2012·Journal of Visualized Experiments : JoVE·Andrew D HughesMichael R King
Jul 10, 2012·Biophysical Journal·Michael J Mitchell, Michael R King
Jul 12, 2012·Frontiers in Oncology·Bryan T GreeneMichael R King
Dec 18, 2012·Nature Nanotechnology·Alessandro ParodiEnnio Tasciotti
Mar 8, 2013·Frontiers in Oncology·Michael J Mitchell, Michael R King
Apr 12, 2013·Science Translational Medicine·Lixin ZhangDario Marchetti
Aug 27, 2013·Cancer Letters·Andrew D HughesMichael R King
Oct 1, 2013·Nature Nanotechnology·Hyeun Joong YoonSunitha Nagrath
Oct 18, 2013·American Journal of Physiology. Cell Physiology·Michael J Mitchell, Michael R King
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael J MitchellMichael R King
Apr 22, 2014·Cell Reports·Xi LuoDaniel A Haber
May 6, 2014·Expert Review of Anticancer Therapy·Michael J Mitchell, Michael R King

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Citations

Jan 14, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yupeng Hong, Qi Zhang
Mar 21, 2016·Medical Oncology·Y C Lim, A P Wiegmans
Mar 21, 2017·Nature Communications·Michael J MitchellRobert Langer
Jun 21, 2017·Chemical Society Reviews·Joshua M JacksonSteven A Soper
Dec 8, 2015·Clinical Chemistry·Klaus Pantel, Catherine Alix-Panabières
Feb 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pi DingRenjun Pei
Dec 13, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiujuan ZhaoMingxian Liu
Mar 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rui HeChangren Zhou
Oct 9, 2015·American Journal of Physiology. Cell Physiology·Michael J MitchellMichael R King
Dec 2, 2020·Cancers·Peng LiuMichiel Stevens
Jan 30, 2018·ACS Nano·Pedro P G GuimarãesMichael J Mitchell

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