Immune activation by nucleic acids: A role in pregnancy complications

Scandinavian Journal of Immunology
B KonečnáB Vlková

Abstract

Cell-free self-DNA or RNA may induce an immune response by activating specific sensing receptors. During pregnancy, placental nucleic acids present in the maternal circulation further activate these receptors due to the presence of unmethylated CpG islands. A higher concentration of cell-free foetal DNA is associated with pregnancy complications and a higher risk for foetal rejection. Cell-free foetal DNA originates from placental trophoblasts. It appears in different forms: free, bound to histones in nucleosomes, in neutrophil extracellular traps (NETs) and in extracellular vesicles (EVs). In several pregnancy complications, cell-free foetal DNA triggers the production of proinflammatory cytokines, and this production results in a cellular and humoral immune response. This review discusses preeclampsia, systemic lupus erythematosus, foetal growth restriction, gestational diabetes, rheumatoid arthritis and obesity in pregnancy from an immunological point of view and closely examines the different pathways that result in maternal inflammation. Understanding the role of cell-free nucleic acids, as well as the biogenesis of NETs and EVs, will help us to specify their functions or targets, which seem to be important in pregnancy co...Continue Reading

References

May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Apr 9, 1999·The Journal of Clinical Investigation·G WallukatF C Luft
Jun 3, 2000·Nature Genetics·M NapireiT Möröy
Aug 2, 2003·The Journal of Biological Chemistry·Shizuo Akira
Jan 13, 2004·Nature Immunology·Eicke LatzDouglas T Golenbock
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
Jan 26, 2005·The Journal of Clinical Investigation·Terry K MeansAndrew D Luster
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas D TaylorCicek Gercel-Taylor
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Mar 17, 2006·Annals of the Rheumatic Diseases·D MakrygiannakisA I Catrina
Nov 17, 2006·Annals of the New York Academy of Sciences·Eirini PapadopoulouGeorgios Nasioulas
May 8, 2007·Journal of Reproductive Immunology·C W G Redman, I L Sargent
Sep 19, 2007·Methods in Molecular Biology·Nicole R BiancoPaul D Robbins
Jan 26, 2008·Clinical Chemistry·Stephen S C ChimY M Dennis Lo
Apr 23, 2009·The Biochemical Journal·Himanshu KumarShizuo Akira
Dec 17, 2009·Cellular & Molecular Immunology·Jian ZhangXian C Li
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·David D Chaplin
Jul 14, 2010·American Journal of Obstetrics and Gynecology·Francesca ColleoniIrene Cetin
Aug 24, 2010·Clinical Chemistry·Anders O H NygrenMathias Ehrich
Jan 12, 2011·Annual Review of Immunology·Roman BarbalatGregory M Barton
May 24, 2011·Clinical Biochemistry·Chunfang QiuMichelle A Williams
May 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea Scharfe-NugentLuke A J O'Neill
Jul 4, 2012·Immunobiology·Anna V CherepanovaPavel P Laktionov
Oct 6, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Chiharu KimuraAkihiko Wakatsuki
Jan 24, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mansour ZamanpoorKaruppiah Thilakavathy
Feb 13, 2013·Arthritis and Rheumatism·Anting Liu CarlsenNiels H H Heegaard
Feb 26, 2013·Journal of Reproductive Immunology·Diana M Morales-PrietoUdo R Markert

❮ Previous
Next ❯

Citations

Nov 30, 2018·Canadian Journal of Physiology and Pharmacology·Marie-Eve BrienSylvie Girard
Jun 7, 2019·Current Opinion in Rheumatology·Luis J JaraMiguel A Saavedra
Aug 9, 2020·Molecular Oncology·Julia ElzanowskaBruno Costa-Silva
Nov 18, 2018·Journal of Cellular Physiology·Zengfang WangYingliang Wang
Mar 13, 2020·Frontiers in Endocrinology·Koumei ShirasunaMasafumi Takahashi
Oct 6, 2020·Frontiers in Immunology·Ingrid AnemanLana McClements
Jun 3, 2020·Current Drug Metabolism·Xuelin GaoRongxia He
Dec 16, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xinxin KeMizu Jiang

❮ Previous
Next ❯

Related Concepts