Immune activation during the implantation phase causes preeclampsia-like symptoms via the CD40-CD40 ligand pathway in pregnant mice

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Keiichi MatsubaraTakashi Matsumoto

Abstract

The CD40 ligand (CD40L) is expressed by T cells and has a critical role in immune system regulation. Interventions targeting CD40L interactions following embryo implantation represent an approach to preventing preeclampsia (PE). To better understand the role of CD40L in PE, we developed a PE mouse model in which we examined how CD40L-induced immune activation affects embryo implantation. Blastocysts were incubated with CD40L-expressing adenovirus and then were transferred into the uterine horns of pseudopregnant ICR mice. Histology, biochemistry and flow cytometry experiments were performed to examine the characteristics of the mouse model. In early pregnancy, decidualization and spiral artery remodeling were reduced in CD40L-transfected mice (CD40L mice) compared with control mice. Hematoxylin-eosin (HE) staining revealed hemorrhaging and excess fibrin deposition at the labyrinth layer-junctional zone interface of the placenta, and PAS staining demonstrated prominent focal and segmental sclerosis with collapsed glomerular capillaries in the kidneys of the CD40L mice. Flow cytometry data showed that interferon-γ production derived from CD4(+) T cells was elevated in the splenic cells of CD40L mice. Blood pressure (measured by t...Continue Reading

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Citations

Mar 24, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Pablo StiefelRocio Muñoz-Hernandez
Sep 15, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kiichiro FuruyaTadashi Kimura
Sep 27, 2018·Journal of Cellular Physiology·Yan LvMingming Lv

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