Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and gamma-IFN levels in serum and cerebrospinal fluid

Journal of the Neurological Sciences
P GalloB Tavolato

Abstract

Serum and cerebrospinal fluid (CSF) levels of interleukin-2 (IL-2), soluble IL-2 receptor (sIL-2R), and gamma-interferon (gamma-IFN) were measured in multiple sclerosis (MS) patients, human immunodeficiency virus type 1 (HIV-1)-infected patients and normal controls (NC). Increased levels of both IL-2 and sIL-2R were found in MS serum. Moreover, 11 of 50 MS patients showed detectable levels of IL-2 in the CSF. HIV-1-infected patients had increased levels of sIL-2R in serum and, less frequently, in the CSF. gamma-IFN was never detected in serum and CSF of all the patients studied. These findings confirm preliminary reports, further stress a systemic T-cell activation in MS, and support the hypothesis that an immunologic disorder exists in such patients.

References

Aug 1, 1988·Annals of Neurology·U Traugott, P Lebon
Dec 1, 1988·Journal of Neuroimmunology·M L CuznerM N Woodroofe
Jun 1, 1988·AIDS Research and Human Retroviruses·P GalloL Chieco-Bianchi
Jan 1, 1987·Annals of the New York Academy of Sciences·R H Schwartz
Nov 1, 1985·Journal of Clinical Immunology·R L HirschK P Johnson
Oct 1, 1983·Neurology·J GolazL Moretta
Mar 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·B H Waksman, W E Reynolds
Apr 1, 1984·Journal of Neuroimmunology·H L WeinerS L Hauser
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jul 28, 2001·Multiple Sclerosis : Clinical and Laboratory Research·J KillesteinR A Van Lier

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Citations

May 1, 1995·Annals of Neurology·S BansilC Rohowsky-Kochan
Jan 1, 1991·Journal of Clinical Apheresis·P C Dau
Apr 1, 1990·Journal of Neurology·D FuchsH Wachter
Aug 1, 1996·Journal of Neurology·P BongioanniG Meucci
Mar 1, 1994·Italian Journal of Neurological Sciences·A R MassaroL Callegaro
Feb 1, 1991·Journal of the Neurological Sciences·P GalloA Sidén
Mar 1, 1992·Journal of the Neurological Sciences·R ScolozziE Paolino
Nov 1, 1992·Journal of the Neurological Sciences·M Deckert-SchlüterG Schwendemann
Dec 1, 1993·Journal of the Neurological Sciences·C Z LuH Link
Nov 1, 1995·Brain Research. Brain Research Reviews·U K Hanisch, R Quirion
May 1, 1991·Journal of Neuroimmunology·J SatohL F Kastrukoff
Feb 14, 1992·Journal of Immunological Methods·M K ShariefE J Thompson
Oct 1, 1996·Journal of Neuroimmunology·F NicolettiA Reggio
Jan 1, 1997·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F SellebjergJ Frederiksen
Feb 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·M K Sharief, E J Thompson
Feb 2, 2008·International Review of Psychiatry·Bruce James Brew, Scott Lee Letendre
Dec 25, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Matthew B WallensteinGary M Shaw

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