PMID: 8509816Feb 1, 1993Paper

Immune adjuvants for chemotherapy or radiotherapy in the 9L rat brain tumor model

Journal of Neuro-oncology
C LiuR A Morantz

Abstract

The therapeutic efficacy and toxicity of three biological response modifiers, Corynebacterium parvum (Cp), Chinese blister beetle extract (CBBE), recombinant human IL-1 alpha (rhIL-1 alpha), used alone or in combination with chemotherapy or radiotherapy, were investigated in the intracerebral (ic) rat 9L brain tumor model. Used alone, Cp (2 mg/rat, ip plus 70 micrograms/rat, ic), CBBE (5 microliters of an ethanol extract, ic), or IL-1 alpha (1 microgram/rat, ic or 1 microgram/rat x 3, q 3 d, ic), had no effect on animal survival compared to the untreated or saline treated controls. When combined with chemotherapy or radiotherapy, the three immunotherapeutic agents did not show any additive effects on survival compared to that observed with systemic BCNU (12 mg/kg), local ic bleomycin (0.25 unit), or local radiotherapy (16 Gy). While ic IL-1 alpha did not produce evident toxicity, there was fatal toxicity caused by ic Cp or CBBE treatment in a few animals. The combination of Cp and bleomycin produced severe neurotoxicity, resulting in the early death of animals. This study demonstrates a lack of efficacy of the nonspecific immune adjuvants IL-1 alpha, Cp or CBBE, used either alone or combined with cytotoxic chemotherapy or radio...Continue Reading

References

Jan 1, 1976·International Journal of Radiation Oncology, Biology, Physics·H MorosonM Schechter
Mar 1, 1977·British Journal of Cancer·T E SadlerJ E Castro
May 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J AllenA Nirenberg
Nov 1, 1990·The American Journal of Medicine·L C Platanias, N J Vogelzang
May 1, 1990·Neurosurgery·M L Rosenblum, N de Tribolet
Jan 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M J OstrowskiW M Martin
May 1, 1989·Journal of Neuro-oncology·J D Kennedy, F K Conley
Jun 1, 1989·Japanese Journal of Cancer Research : Gann·T Ebina, K Ishikawa
Sep 1, 1989·Journal of Ethnopharmacology·G S Wang
Dec 1, 1988·Journal of Ethnopharmacology·T NambaK Inagaki
Dec 1, 1988·Journal of Neurosurgery·M S MahaleyG Y Gillespie
Sep 1, 1986·Immunobiology·Y EndoJ J Oppenheim
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·G PizzaF Corrado
Apr 1, 1981·International Journal of Radiation Oncology, Biology, Physics·S D HendersonR A Morantz
May 1, 1981·International Journal of Radiation Oncology, Biology, Physics·P F Turner

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Citations

Dec 1, 2006·Veterinary and Comparative Oncology·D H Thamm
Apr 26, 2015·Cancer Letters·Nezih HekimEyup Ilker Saygili
Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·L A EverseJ J Battermann

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