Immune adjuvants in early life: targeting the innate immune system to overcome impaired adaptive response

Immunotherapy
Cyro Alves de BritoMaria Notomi Sato

Abstract

The neonatal phase is a transitory period characterized by an absence of memory cells, favoring a slow adaptive response prone to tolerance effects and the development of Th2-type responses. However, when appropriately stimulated, neonates may achieve an immune response comparable with adult counterparts. One strategy to stimulate the immunological response of neonates or children in early infancy has been to explore natural or synthetic ligands of cell receptors to stimulate innate immunity. The use of adjuvants for activating different cell receptors may be the key to enhancing neonatal adaptive immunity. This review highlights recent advances in the emerging field of molecular adjuvants of innate immune response and their implications for the development of immunotherapies, with particular focus on the neonatal period.

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Citations

Mar 9, 2012·Expert Review of Anti-infective Therapy·Eliana Akemi FutataMaria Notomi Sato
Feb 15, 2011·Ageing Research Reviews·Abbe N Vallejo
Nov 11, 2017·Seminars in Immunopathology·Anja Saso, Beate Kampmann
Mar 19, 2019·Journal of Immunology Research·Carolina Argondizo-CorreiaCyro Alves de Brito
Mar 3, 2020·Frontiers in Immunology·Franciane Mouradian Emidio TeixeiraMaria Notomi Sato
Nov 9, 2018·Nutrients·Maria Elisabetta BaldassarreNicola Laforgia
Jan 1, 2021·Oxidative Medicine and Cellular Longevity·Iara Grigoletto FernandesNátalli Zanete Pereira

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