Immune alterations and emerging immunotherapeutic approaches in lung cancer

Expert Opinion on Biological Therapy
Constantin A DasanuNausheen Ahmed

Abstract

Subjects with lung cancer were shown to present a variety of immune abnormalities including cellular immune dysfunction, cytokine alterations, and antigen presentation defects. As discouraging results are commonly seen with the existing therapies in lung cancer, more innovative treatment strategies are needed. The authors review comprehensively the immune abnormalities in individuals with lung cancer, describe the lung cancer immunotherapy candidates that are most advanced in their clinical development, and summarize recent data from clinical trials of these agents. Enhancing the immune system represents an appealing avenue for lung cancer therapy. Several immunomodulating agents have activity in this regard including ipilimumab, a monoclonal antibody against the CTLA-4, and talactoferrin, a dendritic cell activator. In addition, a significant activity was shown with belagenpumatucel-L, a whole-cell-based vaccine that blocks the action of TGF-β2. Other promising vaccines are protein-specific vaccines against tumor antigens such as MAGE-A3, EGF, and MUC1. Although some of these immunotherapies may have lackluster performance as single agents in advanced disease, more impressive results are seen in combination with chemotherapy a...Continue Reading

References

May 1, 1987·Chest·L J WesseliusN A Abdou
Oct 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D YuanJ A Wilder
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Jul 8, 2000·The European Respiratory Journal·A ImadaS Abe
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E S WhiteD A Arenberg
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward Y WooCarl H June
Dec 31, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Canten TataroğluAtilla Akkoçlu
Feb 3, 2005·Nature Immunology·Hans Christian ProbstMaries van den Broek
Aug 30, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Toshihiko IbarakiMizuo Miyazaki
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Béatrice Le Maux ChansacFathia Mami-Chouaib
Aug 11, 2006·The European Respiratory Journal·A BergeronA Tazi
Aug 2, 2007·Journal of Immunotherapy·Hans J J van der VlietMark A Exley
Sep 21, 2007·Nature Reviews. Cancer·Sophie SunAdi F Gazdar
Jan 30, 2008·Molecular and Cellular Biology·Guilin QiaoJian Zhang
Jan 31, 2008·The Journal of International Medical Research·E DundarG Ak
Mar 28, 2008·Immunological Reviews·Magnus JohanssonLisa M Coussens
Jun 12, 2008·International Journal of Cancer. Journal International Du Cancer·Akikazu KawaseAtsushi Ochiai
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Dec 6, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shannon Otsuka, Gwyn Bebb
Apr 14, 2009·Clinical Lung Cancer·Howard Jack West
Apr 14, 2009·Clinical Lung Cancer·Michel M Van den HeuvelNico van Zandwijk
May 12, 2009·International Journal of Cancer. Journal International Du Cancer·Rita RotondoOttavia Barbieri
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Carlo Sorrentino, Emma Di Carlo
Aug 29, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xuewei ZhuangLining Zhang
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming-Yi HoKuang-Hui Sun
Dec 22, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xi ChenZhengtang Chen
Dec 31, 2009·Human Pathology·María José CarliniLilia Susana Lauría de Cidre
Jan 12, 2010·The Journal of Allergy and Clinical Immunology·Theresa L Whiteside
Jan 22, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·D MiottoP Boschetto
Mar 18, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Katsuhiko ShimizuKazuo Tanemoto
Apr 13, 2010·American Journal of Respiratory and Critical Care Medicine·Jean-Paul SculierAnne-Pascale Meert
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerSuzanne L Topalian
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Aug 4, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·David S EttingerUNKNOWN NCCN Non-Small Cell Lung Cancer Panel Members
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick J RobertsMark A Socinski
Nov 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shingo EikawaEiichi Nakayama
Nov 10, 2010·Molecular BioSystems·A J Rader, Stephen M Brown
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ching-Hung ShenJianzhu Chen

❮ Previous
Next ❯

Citations

Dec 7, 2013·Pathology Oncology Research : POR·Nora BittnerLajos Géczi
Jul 10, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Haiyan ChenYueqing Gu
May 28, 2013·The Cancer Journal·Puneeth Iyengar, David E Gerber
Sep 4, 2014·Expert Review of Anticancer Therapy·Simona CarnioGiorgio Vittorio Scagliotti
Sep 26, 2014·Expert Opinion on Emerging Drugs·Francesca CasaluceCesare Gridelli
Feb 12, 2014·Expert Opinion on Biological Therapy·Alexei Shimanovsky, Constantin A Dasanu
Jun 25, 2013·Expert Opinion on Biological Therapy·Vincent VarillaConstantin A Dasanu
Mar 10, 2015·Molecular Immunology·Abhisek SwaikaRichard W Joseph
Jan 17, 2015·Journal of Translational Medicine·Mei JiChang-Ping Wu
May 6, 2016·Expert Review of Respiratory Medicine·Mariacarmela SantarpiaRafael Rosell
Jul 28, 2016·Clinical Lung Cancer·Priyanka KhannaLuis Corrales-Rodriguez
Oct 4, 2016·Journal of the Chinese Medical Association : JCMA·Yuh-Min Chen
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R Brahmer
Apr 2, 2015·Therapeutic Advances in Respiratory Disease·Nicolas GuibertJulien Mazières
Dec 10, 2015·Expert Review of Vaccines·Charles J Russell, Julia L Hurwitz
Jun 24, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Dawn E Dolan, Shilpa Gupta
Mar 4, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valsamo K Anagnostou, Julie R Brahmer
Mar 4, 2018·Current Problems in Cancer·Priya RamanathanRajkumar Thangarajan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.