PMID: 9669087Jul 21, 1998Paper

Immune and biochemical responses of the polychaete Eurythoe complanata exposed to sublethal concentration of copper

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
O NusettiJ Vilas

Abstract

A series of immunoassays, enzyme activity tests and growth rate analyses were conducted on the free living polychaete Eurythoe complanata after 21 day exposure to 0.2 mg.L-1 sublethal nominal concentration of Cu2+ (CuSO45H2O). The immunological assessment was further made immediately after 15 and 30 day post-exposure. Immune cytological parameters, coelomocyte viability and differential coelomocyte counts showed significant differences between exposed an non-exposed worms. Coelomocyte responses to antigenic mouse red blood cells (MRBC), such as formation of secretory (SR) and erythrocyte rosettes (ER), and phagocytosis evidenced significant impairments in the immunological defenses related to copper contamination, related to a two fold increase in Cu-carcass tissue concentration (13.70 +/- 1.50 micrograms.g-1 dry wt, n = 6). The normal immune functions were reestablished upon depuration as tissue Cu content approached basal levels (7.40 +/- 1.70 micrograms.g-1 dry wt, n = 6). Neither enzyme activity of coelomic transaminases as indicators of tissue damage, nor growth rate indexes (carcass tissue RNA/DNA and protein/DNA ratios) were affected by copper exposure. In conclusion, the immunoassays yielded highly sensitive results com...Continue Reading

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Citations

Mar 22, 2007·Archives of Environmental Contamination and Toxicology·Ramón Vázquez-NúñezCarlos Green-Ruíz
Aug 5, 2009·Bulletin of Environmental Contamination and Toxicology·Nuria MéndezRamón Vázquez-Núñez

Related Concepts

Transaminases
Antigens
Cell Density
Cell Survival
Copper
Erythrocytes
Nucleic Acids
Phagocytosis
Myxicola
Immunocytoadherence

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