Immune and gene expression profiling during tacrolimus to everolimus conversion early after liver transplantation.

Human Immunology
James M MathewJosh Levitsky

Abstract

Early elimination of tacrolimus in favor of everolimus can improve renal function in liver transplant recipients. However, as this approach increases the risk of acute rejection, it may benefit from predictive biomarkers guiding weaning. We enrolled 20 recipients on stable tacrolimus + everolimus to undergo tacrolimus withdrawal early post-liver transplant. Blood samples were collected at month 3 (withdrawal initiation), 4 (withdrawal completion), 4.5 and 6 (both everolimus alone). 15 patients did not reject and 5 had mild rejection responding to tacrolimus resumption. Before tacrolimus withdrawal, eventual rejecters had higher percentages of CD56+ NK cells and CD19+CD27+CD24+ memory B cells, and lower levels of T cells expressing the exhaustion marker PD-1. Over time, memory B cells, Ki-67+CD3+ (proliferating) cells and CD4+CD127-CD25HIGH FOXP3+ Tregs increased in rejecters. Tregs also increased in non-rejecters over time. The number of differentially expressed genes progressively increased in rejecters, particularly in mTOR, Eukaryotic Initiation Factor 2, and Neuroinflammation signaling pathways. There was no difference in anti-HLA antibodies between the groups. In summary, blood mononuclear cell and gene expression may pred...Continue Reading

References

Feb 20, 2002·Trends in Neurosciences·Jan Pieter KonsmanRobert Dantzer
Sep 5, 2003·The New England Journal of Medicine·Akinlolu O OjoRobert M Merion
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kyrsten D FairbanksPaul J Thuluvath
Mar 5, 2005·Blood·Manuela BattagliaMaria-Grazia Roncarolo
Dec 2, 2005·The New England Journal of Medicine·Thangamani MuthukumarManikkam Suthanthiran
May 22, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W GaoT B Strom
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heth R TurnquistAngus W Thomson
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paolo De SimoneFrederik Nevens
May 22, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M MasettiG E Gerunda
Jan 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josh LevitskyJoshua Miller
Apr 13, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L FischerH J Schlitt
Aug 14, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P De SimoneUNKNOWN H2304 Study Group
May 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F SalibaUNKNOWN H2304 Study Group
Jun 19, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Lewis TepermanUNKNOWN Spare-the-Nephron Trial Liver Transplantation Study Group
Jan 25, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S K AsraniJ M Millis
Mar 4, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J G O'LearyG B Klintmalm
Jan 31, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F SalibaF Conti
Sep 20, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vadim JucaudMatthew J Everly
Dec 7, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Abraham ShakedPeter H Sayre
Nov 14, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josh LevitskyJames M Mathew
May 2, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Josh LevitskyUNKNOWN Clinical Trials in Organ Transplantation - 14 Consortium

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Shinji Uemoto
The British Journal of Ophthalmology
D B Lake, T R G Poole
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
P De SimoneF Saliba
Journal of Gastrointestinal and Liver Diseases : JGLD
Razvan CiorteaLigia Daniela Blaga
© 2021 Meta ULC. All rights reserved