Jan 1, 2014

Immune approaches to the treatment of breast cancer, around the corner?

Breast Cancer Research : BCR
Carmen CriscitielloGiuseppe Curigliano

Abstract

Immunotherapy for the treatment of breast cancer can be categorized as either (a) specific stimulation of the immune system by active immunization, with cancer vaccines, or (b) passive immunization, such as tumor-specific antibodies (including immune modulators) or adoptive cell therapy that inhibit the function of, or directly kill, tumor cells. We will present the current information and the future perspectives of immunotherapy in patients with breast cancer, including the prognostic role of tumor infiltrating lymphocytes, immune signatures, targeted therapies modulating the immune system, and tumor antigen cancer vaccines. Active immunotherapy in breast cancer and its implementation into clinical trials have been largely a frustrating experience in the last decades. The concept that the immune system regulates cancer development is experiencing a new era of interest. It is clear that the cancer immunosurveillance process indeed exists and potentially acts as an extrinsic tumor suppressor. Also, the immune system can facilitate tumor progression by sculpting the immunogenic phenotype of tumors as they develop. Cancer immunoediting represents a refinement of the cancer immunosurveillance hypothesis and resumes the complex inte...Continue Reading

  • References61
  • Citations14

Mentioned in this Paper

ErbB-2 Receptor
PLAU gene
Monoclonal Antibodies
Tumor Cells, Uncertain Whether Benign or Malignant
Immune Response
Immune System
Microarray Analysis
Tumor Immunity
Diagnostic Radiology Modality
T-Lymphocyte

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