Immune-associated traits measured in milk of Holstein-Friesian cows as proxies for blood serum measurements

Journal of Dairy Science
Scott J DenholmE Wall

Abstract

Previous work has highlighted that immune-associated (IA) traits measurable in blood are associated with health, productivity, and reproduction in dairy cows. The aim of the present study was to determine relationships between IA traits measured in blood serum and those simultaneously measured in milk as well as their association with disease phenotypes. All animals were Holstein-Friesian cows from the Langhill research herd (n = 546) housed at the SRUC Dairy Research Centre in Scotland. Milk and serum samples were collected on 20 separate occasions between July 2010 and March 2015 and analyzed by ELISA for haptoglobin (Hp), tumor necrosis factor-α (TNF-α), and natural antibodies binding keyhole limpet hemocyanin (NAbKLH) and lipopolysaccharide (NAbLPS). Data were analyzed using mixed linear models that included pedigree information. Analyses revealed positive phenotypic correlations between milk and serum NAb (0.59 ≤ r ≤ 0.77), Hp (r = 0.37), and TNF-α (r = 0.12). Milk and serum NAb were also found to have a strong genetic correlation (0.81 ≤ r ≤ 0.94) and were genetically correlated with cow lameness (0.66 and 0.79 for milk NAbKLH and serum NAbLPS, respectively). Clinical mastitis was found to be phenotypically correlated wit...Continue Reading

References

Nov 1, 1989·Immunology Today·P Casali, A L Notkins
Oct 7, 1997·The Journal of Experimental Medicine·S SivoriA Moretta
Nov 5, 1999·Clinical and Diagnostic Laboratory Immunology·A SrinivasanI Tizard
Dec 24, 2002·Current Opinion in Immunology·Chris A BenedictCarl F Ware
Mar 3, 2004·European Journal of Immunology·Anne K StorsetErik Dissen
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·Douglas D BannermanPascal Rainard
May 26, 2004·The Veterinary Journal·H MurataM Yoshioka
Jan 6, 2005·Springer Seminars in Immunopathology·Nicole BaumgarthLeonore A Herzenberg
Nov 21, 2007·Journal of Dairy Science·A T M van KnegselH K Parmentier
Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Joanne Kwak-Kim, Alice Gilman-Sachs
May 8, 2008·Veterinary Research Communications·S R LomborgS Jacobsen
Mar 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Robert F Gilmour
Sep 16, 2009·The Veterinary Journal·Billy I SmithLisa Sherman
Oct 23, 2010·Journal of Dairy Science·T C W PloegaertJ A M van Arendonk
Aug 11, 2011·PloS One·Laurence FloriClaire Rogel-Gaillard
Sep 29, 2011·Preventive Veterinary Medicine·A T M van KnegselH K Parmentier
Dec 24, 2011·Journal of Dairy Science·K A Thompson-CrispiB A Mallard
Nov 1, 2008·Animal : an International Journal of Animal Bioscience·M ClappertonS C Bishop
Jun 23, 2012·Journal of Dairy Science·K A Thompson-CrispiB A Mallard
Nov 29, 2013·Human Reproduction Update·Srividya Seshadri, Sesh Kamal Sunkara
Dec 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saswati Panda, Jeak L Ding
Apr 7, 2015·Journal of Dairy Science·T R CarthyD P Berry
Jan 31, 2017·Journal of Dairy Science·Scott J DenholmEileen Wall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.