Immune-based therapies for hepatocellular carcinoma.

Oncogene
David J PinatoLorenza Rimassa

Abstract

Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death. The immune-rich contexture of the HCC microenvironment makes this tumour an appealing target for immune-based therapies. Here, we discuss how the functional characteristics of the liver microenvironment can potentially be harnessed for the treatment of HCC. We will review the evidence supporting a therapeutic role for vaccines, cell-based therapies and immune-checkpoint inhibitors and discuss the potential for patient stratification in an attempt to overcome the series of failures that has characterised drug development in this disease area.

References

Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y WadaM Kojiro
Jul 27, 2002·Journal of Immunotherapy·Yaling ZhouMichael L Salgaller
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Masahisa JinushiNorio Hayashi
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Mar 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Esther UnittGraeme J M Alexander
Aug 23, 2005·Journal of Reproductive Immunology·Shin-Heng ChiouHo Hong-Nerng
Oct 18, 2005·Molecular and Cellular Biology·Richard V ParryJames L Riley
Apr 14, 2006·Cancer Immunology, Immunotherapy : CII·Nicolas LarmonierEmmanuel Katsanis
May 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa H ButterfieldJames S Economou
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiang GaoZhao-You Tang
Oct 13, 2007·The Journal of Clinical Investigation·Joseph F GrossoCharles G Drake
Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Nov 5, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel H PalmerDavid H Adams
Feb 20, 2009·Journal of Gastroenterology·Melanie Thomas
Jul 25, 2009·Nature Reviews. Immunology·David H Raulet, Nadia Guerra
Dec 10, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alisan KahramanAli Canbay
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Sep 8, 2010·The Journal of Experimental Medicine·Kaori SakuishiAna C Anderson
Jan 8, 2011·International Journal of Cancer. Journal International Du Cancer·Wenxiu ZhaoXiaomin Wang
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frank A SchildbergPercy A Knolle
Jul 16, 2011·Journal of Hepatology·Hiroteru KamimuraYutaka Aoyagi
Jul 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frank A SchildbergPercy A Knolle
Sep 24, 2011·Nature Reviews. Immunology·Fu-Dong ShiLuc Van Kaer
Jan 10, 2012·Annual Review of Immunology·Angelina M Bilate, Juan J Lafaille
Mar 21, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stefania VarchettaMario U Mondelli
Apr 21, 2012·Cancer Cell·Dianne H DapitoRobert F Schwabe
May 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fei ZhaoTim F Greten
May 29, 2012·Current Pharmaceutical Design·Sofia KarkampounaMarianna Kruithof-de Julio
Jan 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard M DunhamArash Grakoui

❮ Previous
Next ❯

Citations

Sep 2, 2020·Journal for Immunotherapy of Cancer·Petros FessasDavid J Pinato
Jun 25, 2020·International Journal of Molecular Sciences·Lucile DumolardZuzana Macek Jilkova
Jan 13, 2021·Stem Cell Reviews and Reports·Lu Liu, Jürgen Borlak
Dec 4, 2020·Critical Reviews in Oncology/hematology·Eleonora LaiMario Scartozzi
Jan 28, 2021·International Journal of Molecular Sciences·Luca BedonMaurizio Polano
Dec 18, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J PinatoLorenza Rimassa
Jan 13, 2021·Pharmaceuticals·Francesca Matilde SchipillitiFabio Gelsomino
Feb 8, 2021·Cancer Treatment and Research Communications·Alessandro Rizzo, Giovanni Brandi
Oct 23, 2020·Vaccines·Mohamed A Abd El AzizRodolfo Sacco
Jan 9, 2021·Current Hepatology Reports·Olga RaevskayaNataliya Razumilava
Feb 17, 2021·Nature Reviews. Gastroenterology & Hepatology·Jordi Gracia-SanchoRubén Francés
Feb 28, 2021·Expert Opinion on Pharmacotherapy·Lucia CerritoFrancesca Romana Ponziani
Feb 23, 2021·Journal of Hepatology·Raffaella Casolino, Chiara Braconi
Apr 2, 2021·Frontiers in Immunology·Rohini Sharma, Leila Motedayen Aval
Apr 3, 2021·Cancer Treatment and Research Communications·Alessandro Rizzo
Apr 7, 2021·Immunotherapy·Alessandro RizzoGiovanni Brandi
Apr 20, 2021·Frontiers in Immunology·Arjuna Singanayagam, Evangelos Triantafyllou
May 7, 2021·Frontiers in Immunology·Yara O AghabiZania Stamataki
Apr 20, 2021·Current Opinion in Oncology·Antonio D'AlessioLorenza Rimassa
Jun 26, 2021·Expert Opinion on Investigational Drugs·Alessandro RizzoGiovanni Brandi
Jul 10, 2021·World Journal of Gastroenterology : WJG·Ângelo Zambam de MattosAngelo Alves de Mattos
Aug 24, 2021·Current Treatment Options in Oncology·Claudia A M FulgenziDavid J Pinato

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT01008358
NCT01853618
NCT02828124
NCT01658878
NCT02576509
NCT02702414
NCT02702401
NCT02383212
NCT02989922
NCT01693562

Software Mentioned

mRECIST

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Journal of Clinical & Cellular Immunology
Dai LiuGuangfu Li
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Zachary J BrownBernd Heinrich
Expert Review of Anticancer Therapy
Sameh MikhailAmer Zeidan
© 2021 Meta ULC. All rights reserved