Immune-based therapy for spinal cord repair: autologous macrophages and beyond

Journal of Neurotrauma
Michal Schwartz, E Yoles

Abstract

Spinal cord injury is a devastating condition of the central nervous system (CNS), often resulting in severe loss of tissue, functional impairment, and only limited repair. Studies over the last few years have shown that response to the insult and spontaneous attempts at repair are multiphasic processes, with varying and sometimes conflicting requirements. This knowledge has led to novel strategies of therapeutic intervention. Our view is that a pivotal role in repair, maintenance, healing, and cell renewal in the CNS, as in other tissues, is played by the immune system. The mode and timing of intervention must be carefully selected, however, as the capacity of the CNS to tolerate local repair mechanisms is limited. Studies have shown that the spontaneously evoked early innate response to CNS injury is characterized by invasion of neutrophils and is unfavorable for cell survival. This is followed by a response of the resident innate immune cells (microglia), which however cannot supply all the needs of the damaged tissue; moreover, once evoked, and for as long as the damage persists, the microglial response remains beyond the capacity of the CNS to tolerate it. Immune-based clinical intervention is most effective in improving f...Continue Reading

References

Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N J Rothwell, P J Strijbos
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Sep 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·O Lazarov-SpieglerM Schwartz
Jan 20, 1997·The Journal of Comparative Neurology·P G PopovichB T Stokes
Jul 11, 1997·Brain Research·I Klusman, M E Schwab
May 26, 1998·Journal of Neuropathology and Experimental Neurology·H Neumann, H Wekerle
Mar 25, 2000·Neurochemistry International·Y L LeeL F Eng
May 18, 2000·Journal of Neuroimmunology·G MoalemM Schwartz
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·O ButovskyM Schwartz
Aug 2, 2001·Journal of Biochemistry·K Nakajima, S Kohsaka
Sep 5, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J A Hanover
May 8, 2002·Nature Reviews. Neuroscience·Minh Dang NguyenSerge Rivest
May 28, 2002·Science·Michal Schwartz, Ehud Hauben
Jun 5, 2002·Current Opinion in Neurology·John R Bethea, W Dalton Dietrich
Jul 20, 2002·Journal of Neuropathology and Experimental Neurology·P G PopovichD M Basso
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Sep 13, 2002·Journal of Neuroimmunology·Jonathan KipnisAuraham Ben-Nur
Nov 5, 2002·Current Opinion in Immunology·Shannon J Turley
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tal MizrahiMichal Schwartz
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan KipnisMichal Schwartz
Nov 15, 2002·The European Journal of Neuroscience·Ehud HaubenMichal Schwartz
Dec 25, 2002·Trends in Pharmacological Sciences·Ehud Hauben, Michal Schwartz
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jan 30, 2003·Journal of Leukocyte Biology·David M Mosser
Mar 1, 2003·Neurobiology of Disease·Benjamin EllezamLisa McKerracher
Jun 10, 2003·Annals of the New York Academy of Sciences·Johan van BeekPhilippe Gasque
Sep 2, 2003·Seminars in Cell & Developmental Biology·Hideyuki OkanoYoshiaki Toyama
Sep 27, 2003·Journal of Neuroimmunology·Yonit BomsteinEti Yoles
Mar 23, 2004·Current Drug Targets. Cardiovascular & Haematological Disorders·Kazuyuki Nakajima, Shinichi Kohsaka
Apr 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Denis GrisLynne C Weaver

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Citations

Dec 4, 2013·Annals of Biomedical Engineering·Nassir Mokarram, Ravi V Bellamkonda
Nov 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Isaac M ChiuMichael C Carroll
Nov 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andres Gottfried-BlackmoreKaren Bulloch
Sep 16, 2009·Journal of Neurotrauma·Brian K KwonWolfram Tetzlaff
Apr 23, 2009·Tissue Engineering. Part a·Yang YangLonnie D Shea
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takuji KurimotoLarry I Benowitz
Apr 11, 2015·International Journal of Molecular Sciences·Arash MoghaddamBahram Biglari
May 17, 2008·Upsala Journal of Medical Sciences·Leif AnderbergAnders Holtz
Aug 29, 2014·Journal of Neuroinflammation·Virginie NeirinckxSabine Wislet
Jul 22, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Martin M MortazaviR Shane Tubbs
Nov 2, 2011·Respiratory Physiology & Neurobiology·James A Windelborn, Gordon S Mitchell
Aug 30, 2011·The Journal of Surgical Research·Yufu WangJinglong Yan
Sep 8, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shushi KabuVinod Labhasetwar
Feb 19, 2009·The European Journal of Neuroscience·Aleksandra KrajacicKarim Fouad
Sep 23, 2008·Glia·Isabelle Pineau, Steve Lacroix
May 19, 2011·Journal of Magnetic Resonance Imaging : JMRI·Peter Cheng-te ChouMehmet Bilgen
Aug 5, 2009·Journal of Cellular and Molecular Medicine·Akop SeksenyanMichal Schwartz
Jul 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Yatma GueyeFrançois Feron
Jul 4, 2015·Neuron·Sachin P GadaniJonathan Kipnis

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