Immune biomarkers alterations in post-traumatic stress disorder: A systematic review and meta-analysis.

Journal of Affective Disorders
Juan-Juan Yang, Wei Jiang

Abstract

Studies have reported the changes of immune biomakers in post-traumatic stress disorder (PTSD), but the results were conflicting. Our aim was to investigate the changes of immune biomarkers in PTSD. Literatures investigating the changes of immune markers in PTSD published in English were systematically searched through PubMed, Embase and Web of Science. We conducted random effects meta-analyses relating PTSD to immune biomarker concentrations and using subgroup analyses to resolve heterogeneity. A total of 2606 articles were screened and 42 samples were included by the systematic review. The levels of interleukin-1β (IL-1β, P = 0.01), IL-2 (P = 0.006), IL-6 (P = 0.0002), interferon-γ (IFN-γ, P = 0.004), tumor necrosis factor-α (TNF-α, P = 0.004), C-reactive protein (CRP, P = 0.0003) and white blood cell (WBC, P = 0.01) were higher in PTSD than healthy controls (HC). Subgroup meta-analyses for psychotropic medication showed the levels of IL-1β and IL-2 were not increased in the PTSD. Subgroup meta-analyses for whether HC exposed to trauma showed the levels of IL-1β and IL-6 were not increased in the PTSD. Egger´s test revealed there was no publication bias. However, there was significant heterogeneity across studies for immune m...Continue Reading

Citations

Jun 24, 2020·Frontiers in Immunology·Ícaro RaonyWilson Savino
Nov 29, 2020·Biology Direct·Alexei VerkhratskyYufang Shi
Aug 1, 2020·Translational Psychiatry·Luca SteardoAlexei Verkhratsky
Nov 7, 2020·Hormone Molecular Biology and Clinical Investigation·Daniele Suzete Persike, Suad Yousif Al-Kass
Jun 1, 2021·BJPsych Advances·Meghna RaviVasiliki Michopoulos
Jun 8, 2021·Neuroscience and Biobehavioral Reviews·Lisa M ChristianClaire M Kamp Dush
Oct 15, 2021·The International Journal of Neuropsychopharmacology·Mary G HornickArun L Jadhav

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