Immune biomarkers in older adults: Role of physical activity

Journal of Toxicology and Environmental Health. Part a
Vanessa ValdiglesiasEduardo Pásaro

Abstract

Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and aging or age-related outcomes, such as sarcopenia, depression, and neurodegenerative disorders. Physical activity is known to improve muscle function and to exert a number of benefits on older adult health, including reduced risk for heart and metabolic system chronic diseases. However, the positive influence of physical activity on the immune system has not been elucidated. In order to shed light on the role of physical activity in immune responses of older individuals, a number of immunological parameters comprising % lymphocyte subsets (CD3+, CD4+, CD8+, CD19+, and CD16+56+) and serum levels of neopterin and tryptophan metabolism products were evaluated in peripheral blood samples of older adults performing normal (N = 170) or reduced (N = 89) physical activity. In addition, the potential influence of other clinical and epidemiological factors was also considered. Results showed that subjects with reduced physical activity displayed significantly higher levels of CD4+/CD8+ratio, kynurenine/tryptophan ratio, and serum n...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Feb 1, 1992·Journal of the Neurological Sciences·T PirttiläH Frey
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·J B HansenB Osterud
Apr 1, 1988·International Journal of Sports Medicine·Y OshidaY Sato
Nov 1, 1994·Journal of Clinical Immunology·L S DiamondstoneW A Blattner
Jun 1, 1993·Immunobiology·G P TilzD Fuchs
Jul 1, 1993·Medicine and Science in Sports and Exercise·D C NiemanS L Nehlsen-Cannarella
Nov 1, 1995·Medicine and Science in Sports and Exercise·S ShinkaiR Shephard
Jul 5, 1996·Science·R A Miller
Jan 1, 1997·European Journal of Applied Physiology and Occupational Physiology·L M CastellE A Newsholme
Feb 1, 1997·Mechanisms of Ageing and Development·K Hirokawa
May 7, 1997·JAMA : the Journal of the American Medical Association·S N MeydaniB D Stollar
Apr 16, 1998·Mechanisms of Ageing and Development·R S MazzeoM Esler
Jun 23, 1999·Medicine and Science in Sports and Exercise·M A CeddiaJ A Woods
Jul 16, 1999·Mechanisms of Ageing and Development·J A WoodsE McAuley
Mar 18, 2000·Advances in Experimental Medicine and Biology·Y ItoY Nagamura
Jun 16, 2000·Mechanisms of Ageing and Development·J L FaheyP Nishanian
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Aug 31, 2001·Neuropsychologia·R BlesaUNKNOWN NORMACODEM Group. NORMAlisation of Cognitive and Functional Instruments for DEMentia
May 11, 2002·Current Drug Metabolism·C MurrD Fuchs
Oct 29, 2002·Brain, Behavior, and Immunity·Bernhard WidnerDietmar Fuchs
Jul 4, 2003·Medicine and Science in Sports and Exercise·Brian K McFarlinGina M Steinhoff
Jul 17, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoher F KapasiJohn L Fahey
Mar 30, 2004·Journal of Psychosomatic Research·Suzi HongPaul J Mills
Jun 23, 2004·Advances in Experimental Medicine and Biology·Yasuhiro ItoYoichi Nagamura
Dec 4, 2004·European Journal of Applied Physiology·Nicolette C BishopAlice C Smith
Jul 5, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kathleen Jentsch-UllrichAstrid Franke
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katharina SchröcksnadelDietmar Fuchs
Nov 5, 2005·Acta Physiologica Hungarica·M UnalG Deniz
Dec 7, 2005·Medicine and Science in Sports and Exercise·John B BartholomewJoseph T Ciccolo
Nov 23, 2006·Experimental Gerontology·Graham Pawelec
Feb 27, 2007·Journal of Psychiatric Research·Shino MagakiWolff M Kirsch
Nov 27, 2007·Journal of Neuroimmunology·Konstantinos BonotisStavros Baloyannis
Nov 30, 2007·Medicine and Science in Sports and Exercise·Vagner RasoValéria Maria Natale
Nov 11, 2008·Neuroscience and Biobehavioral Reviews·J McAfoose, B T Baune
Nov 21, 2008·Clinical and Experimental Hypertension : CHE·Fiorenzo MigniniValentino Streccioni
Jan 9, 2009·Journal of Strength and Conditioning Research·Sergio da Cunha NevesRicardo Jacó de Oliveira
Jan 17, 2009·Mediators of Inflammation·Neha Mathur, Bente Klarlund Pedersen
Apr 25, 2009·Immunology and Allergy Clinics of North America·Jonathan P Godbout, Rodney W Johnson
Jul 25, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniela WeiskopfBeatrix Grubeck-Loebenstein
Aug 7, 2009·The Journal of Nutrition, Health & Aging·Y Rolland, F Pillard
Oct 2, 2009·Circulation·Mercedes CarnethonUNKNOWN Council on Nutrition, Physical Activity and Metabolism

❮ Previous
Next ❯

Citations

Feb 24, 2018·Journal of Toxicology and Environmental Health. Part a·Yeo-Jung KwonYoung-Jin Chun
May 14, 2019·Journal of Toxicology and Environmental Health. Part a·Chunyan YaoTongjian Cai
Jan 16, 2020·Journal of Clinical Medicine·Jadwiga SzymuraJoanna Pera
Sep 24, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mariana Zuccherato BocatoFernando Barbosa
May 4, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Débora da Luz Scheffer, Alexandra Latini
Mar 30, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David GoldeckGraham Pawelec

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
ELISA

Software Mentioned

Cell Quest Pro
STATA
SE

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Journal of Toxicology and Environmental Health. Part a
Vanessa ValdiglesiasBlanca Laffon
Journal of Psychiatric Research
Elke Richartz-SalzburgerKlaus Schott
© 2022 Meta ULC. All rights reserved