Immune cell composition in the endometrium of patients with a complete molar pregnancy: Effects on outcome.

Gynecologic Oncology
Yvonne M HoeijmakersJolanda I J M de Vries

Abstract

In 15% of patients with complete hydatidiform mole (CHM), disease progresses to post-molar gestational trophoblastic neoplasia (GTN) after curettage. Tumor infiltrating lymphocytes (TILs) are essential in overcoming disease in many tumors. Infiltrating lymphocyte composition and density may influence trophoblast regression and development of post-molar GTN. We analyzed immune cell composition and density in curettaged endometrium of patients with CHM which spontaneously regressed, and of patients with CHM which progressed to post-molar GTN. Sixteen patients with CHM and spontaneous regression, and 16 patients with CHM which progressed to post-molar GTN were selected. Immune cell composition and density of natural killer (NK) cells, natural killer T (NKT)-like cells, Cytotoxic T cells, T-Regulatory and T-Helper cells, were determined by multiplex immunohistochemistry (mIHC). Curettaged endometrium of patients with CHM and spontaneous regression contained a slightly higher number of immune cells compared to patients with CHM which progressed to post-molar GTN. NKT-like cell density was significantly higher in patients with spontaneous regression compared to patients with CHM which progressed to post-molar GTN (483 ± 296 vs.295 ± ...Continue Reading

References

Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan E BoysonJack L Strominger
Dec 4, 2003·Tissue Antigens·A Trundley, A Moffett
Jul 20, 2005·The Journal of Experimental Medicine·Indira GuleriaMohamed H Sayegh
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tsuyoshi TachibanaMasayuki Imamura
Nov 9, 2005·The Journal of Experimental Medicine·Nadine Y CroweMark J Smyth
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jonathan E BoysonJack L Strominger
Sep 20, 2007·Gynecologic Oncology·Zoltan NagymanyokiRoss S Berkowitz
Jun 10, 2008·Trends in Immunology·Richard AppsAshley Moffett
Jun 14, 2008·Biology of Reproduction·Elizabeth S TaglauerMargaret G Petroff
Aug 22, 2008·Immunological Investigations·J E BoysonA Chant
Dec 6, 2008·Advances in Cancer Research·Masaki Terabe, Jay A Berzofsky
Apr 17, 2009·The New England Journal of Medicine·Ross S Berkowitz, Donald P Goldstein
Jan 9, 2010·American Journal of Reproductive Immunology : AJRI·Irit Manaster, Ofer Mandelboim
Aug 3, 2010·Lancet·Michael J SecklRoss S Berkowitz
Jun 21, 2011·Gynecologic Oncology·Mo'iad AlazzamJohn Tidy
Aug 30, 2011·Journal of Leukocyte Biology·Olympe ChazaraAshley Moffett
Jan 10, 2013·Annual Review of Immunology·Adrian Erlebacher
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Feb 18, 2016·Journal for Immunotherapy of Cancer·Edward C StackPeter P Lee
Jul 1, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Emanuela VerasIe-Ming Shih
Aug 16, 2016·The Journal of Clinical Investigation·Adil I DaudMichael D Rosenblum
Jan 7, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pierre-Adrien BolzeBenoît You
May 13, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Peng ZhaoWeiguo Lu
Nov 17, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark A J GorrisCarl G Figdor
Aug 31, 2018·Frontiers in Immunology·Masaki Terabe, Jay A Berzofsky

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