Immune Cell Dynamics Unfolded by Single-Cell Technologies

Frontiers in Immunology
Daniel J KunzKylie R James

Abstract

The single-cell revolution is paving the way towards the molecular characterisation of every cell type in the human body, revealing relationships between cell types and states at high resolution. Changes in cellular phenotypes are particularly prevalent in the immune system and can be observed in its continuous remodelling up to adulthood, response to disease and development of immunological memory. In this review, we delve into the world of cellular dynamics of the immune system. We discuss current single-cell experimental and computational approaches in this area, giving insights into plasticity and commitment of cell fates. Finally, we provide an outlook on upcoming technological developments and predict how these will improve our understanding of the immune system.

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Citations

Mar 19, 2019·Annual Review of Biomedical Engineering·Yanxiang DengRong Fan
Feb 8, 2020·Annual Review of Analytical Chemistry·Mai YamagishiYoshitaka Shirasaki
Aug 25, 2020·PLoS Computational Biology·Xiaomei LiThuc D Le
Feb 12, 2019·Frontiers in Immunology·Romy E Hoeppli, Anne M Pesenacker
Oct 18, 2019·The European Respiratory Journal·Howard H F TangMichael Inouye
Sep 15, 2020·Frontiers in Molecular Biosciences·Anca F SavulescuMusa M Mhlanga
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Sep 14, 2020·IScience·Maya M L Poon, Donna L Farber
Feb 19, 2021·The Journal of Experimental Medicine·Puneeth GuruprasadMarco Ruella
May 20, 2021·Immunological Reviews·Dillon G PattersonJeremy M Boss

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Datasets Mentioned

BETA
GSE75478

Methods Mentioned

BETA
Fluorescence-Activated Cell Sorting
FACS
Smart-seq
InDrop
scRNA-seq
RNA-seq
single-cell
ATAC-seq

Software Mentioned

Smart
Monocle
well
scTCRseq
BASIC
TraCeR
seq2
TRAPeS
FACS
Seq

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