Immune cell infiltration-based signature for prognosis and immunogenomic analysis in breast cancer.

Briefings in Bioinformatics
Shiyuan WangLei Yang

Abstract

Breast cancer is one of the most human malignant diseases and the leading cause of cancer-related death in the world. However, the prognostic and therapeutic benefits of breast cancer patients cannot be predicted accurately by the current stratifying system. In this study, an immune-related prognostic score was established in 22 breast cancer cohorts with a total of 6415 samples. An extensive immunogenomic analysis was conducted to explore the relationships between immune score, prognostic significance, infiltrating immune cells, cancer genotypes and potential immune escape mechanisms. Our analysis revealed that this immune score was a promising biomarker for estimating overall survival in breast cancer. This immune score was associated with important immunophenotypic factors, such as immune escape and mutation load. Further analysis revealed that patients with high immune scores exhibited therapeutic benefits from chemotherapy and immunotherapy. Based on these results, we can conclude that this immune score may be a useful tool for overall survival prediction and treatment guidance for patients with breast cancer.

References

Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Jul 3, 2008·Cancer Research·Marcus SchmidtMathias Gehrmann
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew H BeckRobert B West
Oct 8, 2011·Breast Cancer Research : BCR·Achim RodyManfred Kaufmann
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Jan 18, 2013·BMC Bioinformatics·Sonja HänzelmannJustin Guinney
Mar 8, 2013·PLoS Computational Biology·Wei-Yi ChengDimitris Anastassiou
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Apr 19, 2013·Science Translational Medicine·Wei-Yi ChengDimitris Anastassiou
Sep 26, 2013·Nature Reviews. Cancer·Caitriona HolohanPatrick G Johnston
Oct 12, 2013·Nature Communications·Kosuke YoshiharaRoel G W Verhaak
Jun 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael D IglesiaJonathan S Serody
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Mar 31, 2015·Nature Methods·Aaron M NewmanAsh A Alizadeh
Apr 22, 2015·Cancer Biology & Therapy·Phillip P Santoiemma, Daniel J Powell
Sep 12, 2015·Science·Eliezer M Van AllenLevi A Garraway
Oct 10, 2015·Cell·Giovanni CirielloCharles M Perou
Mar 12, 2016·Current Opinion in Immunology·Davide BedognettiBarbara Seliger
May 22, 2016·Bioinformatics·Zuguang GuMatthias Schlesner
Aug 25, 2017·Molecular Cancer Therapeutics·Aaron M GoodmanRazelle Kurzrock
Oct 21, 2017·Nature Communications·Chan-Young OckJu-Seog Lee
Nov 21, 2017·Journal of the National Cancer Institute·Anshuman PandaShridar Ganesan

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Citations

Jul 2, 2020·Scientific Reports·Xiangchun YuYing Xu
Sep 15, 2020·OncoTargets and Therapy·Huan SongJianming Wang
Oct 24, 2020·Cancers·Qizhan Luo, Thomas-Alexander Vögeli
Mar 5, 2021·Cancer Immunology, Immunotherapy : CII·Xian-Ning WuNan Zhang
Oct 26, 2021·Frontiers in Cell and Developmental Biology·Qingshan HuangWei Guo

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