Immune cell trafficking in uterus and early life is dominated by the mucosal addressin MAdCAM-1 in humans

Gastroenterology
M SalmiS Jalkanen

Abstract

In adults, binding of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) to lymphocyte alpha4beta7 integrin directs cell trafficking to gut, whereas interaction of peripheral node addressins (PNAd) with lymphocyte L-selectin targets immune cells to peripheral lymph nodes (PLNs). Because nothing is known about these addressins during human development, we studied the expression and function of MAdCAM-1 (and PNAd for comparison) in fetuses and children. Series of human tissue samples obtained from fetuses (7-40 weeks), children (2 months-7 years), and adults were immunostained with monoclonal antibodies. The function of the addressins and their lymphocyte counter-receptors was tested in in vitro binding assays on fetal and adult tissues. Unlike in adults, MAdCAM-1 is widely expressed from embryonic week 7 onwards, and it only gradually becomes polarized to mucosal vessels after birth. In utero MAdCAM-1 functionally governs lymphocyte adhesion to vessels both in the gut and PLNs by binding to alpha4beta7 integrin. The later induction of PNAd gradually starts to dominate the binding of lymphocytes to PLNs during childhood. There are striking age-dependent switches and species-specific variation in the molecular mechanisms of lym...Continue Reading

Citations

Aug 16, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Parvaneh RafieeDavid G Binion
Jul 31, 2004·Immunology and Cell Biology·Euphemia LeungGeoffrey W Krissansen
Jan 27, 2006·World Journal of Gastroenterology : WJG·Silvio DaneseAntonio Gasbarrini
Jan 18, 2020·Expert Opinion on Biological Therapy·Ferdinando D'AmicoLaurent Peyrin-Biroulet
Jul 29, 2005·Immunological Reviews·Marko Salmi, Sirpa Jalkanen
Apr 16, 2003·International Journal of Experimental Pathology·A AlaH J Hodgson
Jul 15, 2015·Oncoimmunology·Ann Ager, Michael J May
Jun 8, 2018·Mucosal Immunology·Fatima NawazJames Arthos
Jan 3, 2019·Current Opinion in HIV and AIDS·Claudia CicalaAnthony S Fauci
Nov 7, 2003·Current Gastroenterology Reports·Stephen J BickstonFabio Cominelli
May 17, 2014·Immunology·Kaisa AuvinenMarko Salmi
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·David J TophamAndrea Sant
Mar 14, 2021·Nature Reviews. Gastroenterology & Hepatology·Raja Atreya, Britta Siegmund
Jul 1, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marisol VenyJulián Panés

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.