Immune Cell Trafficking to the Liver

Transplantation
Sulemon ChaudhryAdam Griesemer

Abstract

The human liver is an organ with a diverse array of immunologic functions. Its unique anatomic position that leads to it receiving all the mesenteric venous blood, combined with its unique micro anatomy, allows it to serve as a sentinel for the body's immune system. Hepatocytes, biliary epithelial cells, Kupffer cells, stellate cells, and liver sinusoidal endothelial cells express key molecules that recruit and activate innate and adaptive immunity. Additionally, a diverse array of lymphoid and myeloid immune cells resides within and traffics to the liver in specific circumstances. Derangement of these trafficking mechanisms underlies the pathophysiology of autoimmune liver diseases, nonalcoholic steatohepatitis, and liver transplantation. Here, we review these pathways and interactions along with potential targets that have been identified to be exploited for therapeutic purposes.

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Citations

Aug 23, 2019·Bone Marrow Transplantation·Megan Sykes, Adam D Griesemer
Sep 1, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haiyang XieHangxiang Wang
Nov 24, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason M ZimmererGinny L Bumgardner

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