Immune cells and inflammation in AKI to CKD progression

American Journal of Physiology. Renal Physiology
Yuki Sato, Motoko Yanagita

Abstract

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic denominators including cell death/injury, inflammation, and fibrosis, regardless of the initiating insults. Recent clinical studies have shown that a single episode of AKI can lead to subsequent chronic kidney disease (CKD). Although the involvement of multiple types of cells in the pathophysiology of AKI is becoming increasingly clear, the precise mechanisms for this "AKI to CKD progression" are still unknown, and no drug has been shown to halt this progression. An increasing number of epidemiological studies have also revealed that the presence of aging greatly increases the risk of AKI to CKD progression, and chronic inflammation is increasingly recognized as an important determinant factor for this progression. In this review article, we first describe the current understanding of the pathophysiology of AKI to CKD progression based on multiple types of cells. In particular, we will highlight the recent findings in regard to the mechanisms for chronic inflammation after AKI. Subsequently, we will focus on the mechanisms responsible for the increased ...Continue Reading

References

Mar 1, 1986·The American Journal of Medicine·S Anderson, B M Brenner
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J NeugartenB Kasiske
Sep 1, 2000·American Journal of Physiology. Renal Physiology·H RabbW W Tang
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roy G CutlerMark P Mattson
Nov 3, 2004·The Journal of Clinical Investigation·Janakiraman KrishnamurthyNorman E Sharpless
Nov 25, 2004·American Journal of Physiology. Renal Physiology·Yuan-Ji DayMark D Okusa
Nov 25, 2004·PLoS Biology·Graham E J RodwellStuart K Kim
Jul 29, 2005·Journal of the American Society of Nephrology : JASN·Wendy E HoyKerstin Amann
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Nov 18, 2005·Journal of the American Society of Nephrology : JASN·Masaomi Nangaku
Apr 14, 2006·European Heart Journal·Carmelinda RuggieroLuigi Ferrucci
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li LiMark D Okusa
Jul 13, 2007·American Journal of Physiology. Renal Physiology·Markus HörbeltTimothy A Sutton
Sep 15, 2007·The Journal of Clinical Investigation·Huiling WuSteven J Chadban
Feb 22, 2008·American Journal of Physiology. Renal Physiology·Roland Schmitt, Lloyd G Cantley
Mar 29, 2008·Cell Stem Cell·Benjamin D HumphreysJoseph V Bonventre
May 31, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Roland SchmittChirag R Parikh
Jul 25, 2008·Nature·Ruslan Medzhitov
Nov 21, 2008·Journal of the American Society of Nephrology : JASN·Areef IshaniAllan J Collins
Jul 25, 2009·Kidney International·Maria Teresa GandolfoHamid Rabb
Jan 19, 2010·Annual Review of Pathology·Jean-Philippe CoppéJudith Campisi
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shuei-Liong LinJeremy S Duffield
Mar 23, 2010·Cell·Carl Nathan, Aihao Ding
May 4, 2010·Nature Medicine·Li YangJoseph V Bonventre
May 5, 2010·Annals of Internal Medicine·Andrew D RuleMark D Stegall
May 7, 2010·Trends in Molecular Medicine·Adam FreundJudith Campisi
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Jan 7, 2011·Journal of the American Society of Nephrology : JASN·Sharon AndersonKevin P High
Feb 4, 2011·Journal of the American Society of Nephrology : JASN·Sik LeeLloyd G Cantley
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Benjamin D HumphreysJoseph V Bonventre
Aug 16, 2011·Developmental Cell·Annika ArmulikChrister Betsholtz
Sep 14, 2011·The Journal of Clinical Investigation·Nariaki AsadaMotoko Yanagita
Oct 4, 2011·Journal of the American Society of Nephrology : JASN·Hai-Chun YangAgnes B Fogo
Nov 3, 2011·The Journal of Clinical Investigation·Joseph V Bonventre, Li Yang
Nov 25, 2011·Kidney International·Steven G CocaChirag R Parikh
Dec 3, 2011·Journal of the American Society of Nephrology : JASN·Peter J NelsonJeremy Duffield
Dec 14, 2011·Kidney International·Ion D BucaloiuRobert M Perkins
Jan 10, 2012·Circulation Research·Nikolaos G Frangogiannis
Feb 4, 2012·Genes & Development·Matthew S Hayden, Sankar Ghosh
Mar 3, 2012·Journal of the American Society of Nephrology : JASN·Claudia SchrimpfJeremy S Duffield
Mar 23, 2012·Kidney International·Ivica GrgicJoseph V Bonventre

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Citations

Sep 4, 2019·Nature Reviews. Nephrology·Yuki Sato, Motoko Yanagita
Mar 4, 2020·International Journal of Molecular Sciences·Mi Ra NohBabu J Padanilam
Jun 17, 2020·American Journal of Physiology. Renal Physiology·Alejandro R ChadeGene L Bidwell
Sep 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui-Zhi TanLi Wang
Jun 26, 2020·Frontiers in Physiology·Junyu LuPinhu Liao
Mar 10, 2020·American Journal of Physiology. Renal Physiology·Jenny L M DigbyVeronika Sander
Sep 19, 2019·American Journal of Physiology. Renal Physiology·Ying FuZheng Dong
Jul 19, 2019·Journal of the American Society of Nephrology : JASN·Leyuan XuLloyd G Cantley
Oct 16, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yuki Sato, Motoko Yanagita
Feb 16, 2019·Stem Cells International·Quan ZhuangYingzi Ming
Oct 9, 2019·International Journal of Molecular Sciences·Francesco GuzziElena Lazzeri
Aug 17, 2020·The Journal of Experimental Medicine·Miyako TanakaTakayoshi Suganami
Jan 21, 2021·Experimental Biology and Medicine·Heidi A Creed, Joseph M Rutkowski
Feb 7, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jinkun Xia, Wangsen Cao
Feb 9, 2021·British Journal of Pharmacology·Didier Portilla, Sandhya Xavier
Feb 2, 2021·Clinical Pharmacology and Therapeutics·Manjunath P Pai
Mar 9, 2021·Frontiers in Physiology·Tingting LiShougang Zhuang
Mar 24, 2021·Critical Care Clinics·Javier A Neyra, Lakhmir S Chawla
Mar 30, 2021·Clinical Kidney Journal·Stephen J McWilliamLouise Oni
May 6, 2021·Immunological Reviews·Hiroyuki AraiMotoko Yanagita
Jul 10, 2021·Frontiers in Pharmacology·Laura Marquez-ExpositoMarta Ruiz-Ortega
Jul 10, 2021·Journal of Clinical Laboratory Analysis·Hai-Yuan LuHai-Tao Jiang
Jul 11, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yuki SatoMotoko Yanagita
Nov 29, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cheng-You WangJames Cheng-Chung Wei
Sep 21, 2021·Experimental and Therapeutic Medicine·Lishi ShaoLi Yang
Nov 23, 2021·Physiological Reports·Gaurav BaranwalJoseph M Rutkowski
Nov 24, 2021·The Journal of Clinical Investigation·Yuki SatoMotoko Yanagita
Jan 13, 2022·Journal of the American Society of Nephrology : JASN·Sherry G MansourUNKNOWN ASSESS-AKI Consortium

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Methods Mentioned

BETA
dissect
biopsy

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