Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation.

Frontiers in Immunology
Jessica M ToothakerLiza Konnikova

Abstract

Intra-amniotic (IA) inflammation is associated with significant morbidities for both the mother and the fetus. Prior studies have illustrated many of the effects of IA inflammation on the uterine lining (decidua) and membranous layers of the placenta at the fetal-maternal interface. However, much less is known about the immunological response occurring within the villous placenta. Using a rhesus macaque model of lipopolysaccharide (LPS)-induced IA inflammation, we showed that pregnancy-matched choriodecidua and villi have distinct immunological profiles in rhesus pregnancies. In the choriodecidua, we show that the abundance of neutrophils, multiple populations of antigen-presenting cells, and two populations of natural killer (NK) cells changes with prenatal IA LPS exposure. In contrast, in immune cells within the villous placenta we observed alterations in the abundance of B cells, monocytes, and CD8 T cells. Prior work has illustrated that IA inflammation leads to an increase in tumor necrosis factor alpha (TNFα) at the fetal-maternal interface. In this study, pretreatment with a TNFα blockade partially reversed inflammation in the placental villi. Furthermore, we report that immune cells in the villous placenta sensed LPS du...Continue Reading

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Citations

Oct 27, 2020·Frontiers in Immunology·Emily F CornishThomas McDonnell
Nov 17, 2021·American Journal of Perinatology·Christina J MegliSteve N Caritis

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Methods Mentioned

BETA
single-cell sequencing
Cesarean section
Flow Cytometry
FCS
PMA

Software Mentioned

GraphPad Prism
table
R
CyTOF
Premium Cytobank®
Cytobank
Premium Cytobank
PMCMR
Phenograph
cytofkit R package

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