Immune checkpoint blockade: the role of PD-1-PD-L axis in lymphoid malignancies

OncoTargets and Therapy
Cristina IlcusMihnea Zdrenghea

Abstract

The co-inhibitory receptor programmed cell death (PD)-1, expressed by immune effector cells, is credited with a protective role for normal tissue during immune responses, by limiting the extent of effector activation. Its presently known ligands, programmed death ligands (PD-Ls) 1 and 2, are expressed by a variety of cells including cancer cells, suggesting a role for these molecules as an immune evasion mechanism. Blocking of the PD-1-PD-L signaling axis has recently been shown to be effective and was clinically approved in relapsed/refractory tumors such as malignant melanoma and lung cancer, but also classical Hodgkin's lymphoma. A plethora of trials exploring PD-1 blockade in cancer are ongoing. Here, we review the role of PD-1 signaling in lymphoid malignancies, and the latest results of trials investigating PD-1 or PD-L1 blocking agents in this group of diseases. Early phase studies proved very promising, leading to the clinical approval of a PD-1 blocking agent in Hodgkin's lymphoma, and Phase III clinical studies are either planned or ongoing in most lymphoid malignancies.

Citations

Feb 9, 2018·Journal of Clinical and Experimental Hematopathology : JCEH·Ayako SakakibaraKei Kohno
Aug 27, 2018·Journal of Cellular Biochemistry·Hui LiYao-Zhou Tian
Oct 24, 2018·Cytometry. Part B, Clinical Cytometry·Ravnit-Kaur GrewalJonathan R Fromm
Jul 21, 2017·Nature Reviews. Disease Primers·Shaji K KumarKenneth C Anderson
Nov 4, 2017·Wiener klinische Wochenschrift·Christiane ThallingerChristoph Zielinski
Jun 8, 2018·Clinical and Experimental Medicine·Amro Mohamed Sedky El-GhammazMohamad Ayed Mohamad
Jan 26, 2018·Asia-Pacific Journal of Clinical Oncology·Ziwei LiaoYangqiu Li
May 8, 2019·Journal for Immunotherapy of Cancer·Sonja AlthammerKeith E Steele
Mar 7, 2021·Clinical and Experimental Immunology·Fang LiHongmei Jing
Apr 4, 2021·Pharmaceuticals·Laura JimbuMihnea Zdrenghea
Apr 4, 2021·European Journal of Immunology·Jan P NicolayEmilio Berti

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