Immune Checkpoint Inhibitor-induced Thyroid Dysfunction Is Associated with Higher Body Mass Index.

The Journal of Clinical Endocrinology and Metabolism
Rena M PollackRivka Dresner-Pollak

Abstract

Obesity is a proinflammatory metabolic state that may play a role in the development of immune-related adverse events (irAEs) associated with immune checkpoint inhibitor therapy. To characterize the association between body mass index (BMI) and thyroid irAEs. We performed a single-center, retrospective analysis of 185 cancer patients treated with anti-PD-1/L1 from January 2014 to December 2018. Patients with normal thyroid function at baseline and available BMI were included. The primary endpoint was difference in BMI in patients who developed overt thyroid dysfunction versus those who remained euthyroid following anti-PD-1/L1 initiation. Additional endpoints included any (overt or subclinical) thyroid dysfunction, overt thyrotoxicosis or overt hypothyroidism, and time to development of dysfunction according to BMI. Any thyroid dysfunction developed in 72 (38.9%) patients and 41 (22.1%) developed overt thyroid dysfunction. Mean BMI was higher in those with overt thyroid dysfunction versus euthyroid (27.3 ± 6.0 vs 24.9 ± 4.5, P = .03). Development of overt thyrotoxicosis versus remaining euthyroid was associated with higher BMI (28.9 ± 5.9 vs 24.9 ± 4.5; P < .01), whereas overt hypothyroidism was not (26.7 ± 5.5 vs 24.9 ± 4.5, P...Continue Reading

References

Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Joseph G HollowellLewis E Braverman
Sep 10, 2002·The Lancet Oncology·France BianchiniHarri Vainio
Mar 21, 2007·Diabetes Care·K M V NarayanDavid F Williamson
May 25, 2010·Diabetes Research and Clinical Practice·Asnawi AbdullahJohannes Stoelwinder
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Ken K OngUNKNOWN Medical Research Council National Survey of Health and Development Scientific and Data Collection Teams
Jan 10, 2014·The Journal of Endocrinology·Haiming Cao
Aug 6, 2014·Autoimmunity Reviews·Mathilde VersiniYehuda Shoenfeld
Oct 1, 2014·Nature Reviews. Endocrinology·Rudolf Kaaks, Tilman Kühn
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Jul 23, 2015·The Journal of Dermatology·Tomohiko NaritaAkira Kawada
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Mar 6, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander P R BallyJeremy M Boss
Aug 1, 2016·Current Oncology Reports·Hannah LennonAndrew G Renehan
Nov 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Jeroen de FiletteBert Bravenboer
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Feb 18, 2017·The New England Journal of Medicine·Joaquim BellmuntUNKNOWN KEYNOTE-045 Investigators
Sep 12, 2017·The New England Journal of Medicine·Jedd D WolchokJames Larkin
Mar 31, 2018·Journal of the Endocrine Society·Tomoko KobayashiHiroshi Arima
Aug 23, 2018·Thyroid : Official Journal of the American Thyroid Association·Priyanka C IyerRamona Dadu
Apr 24, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rena M PollackRivka Dresner-Pollak
Dec 10, 2019·Thyroid : Official Journal of the American Thyroid Association·Anupam KotwalMabel Ryder
Feb 29, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alessio CortelliniPaolo A Ascierto

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Citations

Feb 20, 2021·Frontiers in Oncology·Tiffany ScullyEmily Jane Gallagher
Apr 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Christopher A MuirAlexander M Menzies

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