Immune Checkpoint Inhibitors: An Innovation in Immunotherapy for the Treatment and Management of Patients with Cancer

Asia-Pacific Journal of Oncology Nursing
Jennifer DineMargaret Barton-Burke

Abstract

Cancer survival rates are generally increasing in the United States. These trends have been partially attributed to improvement in therapeutic strategies. Cancer immunotherapy is an example of one of the newer strategies used to fight cancer, which primes or activates the immune system to produce antitumor effects. The first half of this review paper concisely describes the cell mechanisms that control antitumor immunity and the major immunotherapeutic strategies developed to target these mechanisms. The second half of the review discusses in greater depth immune checkpoint inhibitors that have recently demonstrated tremendous promise for the treatment of diverse solid tumor types, including melanoma, non-small cell lung cancer, and others. More specifically, the mechanisms of action, side effects, and patient and family management and education concerns are discussed to provide oncology nurses up-to-date information relevant to caring for cancer-affected patients treated with immune checkpoint inhibitors. Future directions for cancer immunotherapy are considered.

References

Oct 15, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Tianhai TianAngus Harding
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Mar 23, 2012·Nature Reviews. Cancer·Karolina Palucka, Jacques Banchereau
Jun 19, 2013·The Oncologist·Leslie A FecherJeffrey S Weber
Jul 3, 2013·Nature Reviews. Drug Discovery·Asher Mullard
Dec 12, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jyoti D PatelBruce J Roth
Jan 1, 2014·Cancer Management and Research·Blanca Ledezma, Annie Heng
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
May 29, 2014·Clinical Journal of Oncology Nursing·Rajni KannanStephanie Andrews
Mar 18, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Matthew HowellPaul Lorigan
Jul 25, 2015·Nature Reviews. Cancer·Ignacio MeleroJohn Haanen
Aug 12, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria L Chiou, Mauricio Burotto
Apr 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lars HofmannLucie M Heinzerling
May 4, 2016·Current Opinion in Oncology·Samer TabchiNormand Blais
Jul 13, 2016·The Oncologist·Jeffrey S WeberDirk Schadendorf
Feb 13, 2017·The Nursing Clinics of North America·Margaret Barton-BurkeSean Burke

❮ Previous
Next ❯

Citations

Feb 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerUNKNOWN National Comprehensive Cancer Network
Sep 26, 2017·International Journal of Cancer. Journal International Du Cancer·Siqi GuoStephen J Beebe
Feb 15, 2018·Muscle & Nerve·Stephanie OngTalal Mansy
Jan 10, 2019·Future Oncology·Albert SemaanElie Nemr
Feb 16, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Neha Kumar, Hesham Abboud
May 10, 2019·International Journal of Molecular Sciences·Debarati BanikAlejandro Villagra
Jun 22, 2019·Chemical Communications : Chem Comm·Cristina NativiStefano Roelens
Jun 4, 2019·AACN Advanced Critical Care·Nancy Munro
Oct 31, 2019·Microbiology and Immunology·Maria TerrívelAna Miguel Matos
Dec 14, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·Y d'HarguesB Böll
Dec 6, 2018·Advanced Healthcare Materials·Vardhman Kumar, Shyni Varghese
Feb 14, 2019·Archives of Pharmacal Research·Sri Murugan Poongkavithai VadevooByungheon Lee
Jan 10, 2019·World Journal of Gastroenterology : WJG·Monjur Ahmed
Feb 18, 2020·Proceedings·James LopezAppalanaidu Sasapu
Jun 28, 2019·Frontiers in Endocrinology·Jin SothornwitChatlert Pongchaiyakul
Dec 6, 2018·Journal of Cellular Physiology·Nasser Hashemi GoradelArash Arashkia
Nov 30, 2019·Case Reports in Rheumatology·Bicky ThapaCassandra Calabrese
Mar 17, 2018·Journal of Hematology & Oncology·Julian A Marin-AcevedoYanyan Lou
Jan 20, 2019·Clinical Science·Jitwadee InthagardAntonia K Roseweir
Mar 25, 2019·Oncoimmunology·Pranav MurthyMichael T Lotze
Jul 3, 2019·Expert Opinion on Investigational Drugs·Alice GuazzelliLuciano Mutti
May 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Shiao Li OeiFriedemann Schad
Oct 7, 2020·Vaccines·Manuel MorgadoFátima Roque
Oct 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eun-Hye KimJun Akimoto
Nov 24, 2020·Journal of Immunoassay & Immunochemistry·Varun Dhiman, Deepak Pant
Jan 12, 2021·Journal for Immunotherapy of Cancer·Jordana GriffithsMark S Cragg
Jan 6, 2021·Journal of Clinical Medicine·Tania PereiraHélder P Oliveira
Jan 15, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Dushyant Singh DahiyaManidhar Lekkala
Apr 1, 2018·Current Pharmacology Reports·Prema NedungadiAsha B Pillai
Feb 22, 2021·The Ocular Surface·Royce B ParkJennifer Park

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.