Immune checkpoint inhibitors in malignant lymphoma: Advances and perspectives

Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu
Ningjing LinJ Zhu

Abstract

Classical Hodgkin lymphoma (cHL) has been identified with universal genetic alterations of chromosome 9p24.1, which contains PD-L1/PD-L2 genes. The amplification of 9p24.1 is associated with the increased expression of PD-L1 and PD-L2 on RS cells, which promotes their immune evasion, and subsequently makes cHL sensitive to PD-1 blockade. Several PD-1 inhibitors have shown significant efficacies with overall response rate (ORR) of 70%-90% in relapse/refractory (r/r) cHL and have acquired the approvals for this indication. Recently, more and more studies are conducted to investigate PD-1 blockade in earlier disease course and in combination with neo-agents or chemotherapy. Unlike cHL, non-Hodgkin lymphoma (NHL) consists of numerous subtypes harboring highly biological heterogeneity. Only a few subtypes have been shown to have genetic alteration of9p24.1 including primary mediastinal B cell lymphoma (PMBL), gray zone lymphoma (GZL) with features intermediate between diffuse large B cell lymphoma (DLBCL) and cHL, primary central nervous system lymphoma (PCNSL) and primary testicular lymphoma (PTL). Epstein-Barr virus (EBV)-associated lymphomas have a virally mediated overexpression of PD-L1, also making them sensitive to PD-1 block...Continue Reading

Citations

Dec 3, 2020·Vaccines·Robert PytlikPavel Klener
Mar 26, 2021·International Immunopharmacology·Xiaoxu Li, Wenling Zhang
Apr 20, 2021·Frontiers in Oncology·Wei ZhangZhen Cai
Jun 3, 2021·Viruses·Nathália Alves Araújo de AlmeidaVanessa Salete de Paula

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Methods Mentioned

BETA
ICE
biopsy

Clinical Trials Mentioned

NCT02684292
NCT01896999
NCT03138499
NCT02950220
NCT02940301
NCT03471351
NCT03015896
NCT02875067
NCT03150329
NCT03179930

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