Immune checkpoints aberrations and gastric cancer; assessment of prognostic value and evaluation of therapeutic potentials

Critical Reviews in Oncology/hematology
Omar Abdel-Rahman

Abstract

Till now, the prognosis of advanced gastric cancer looked dreadful; thus the search for newer better approaches for this lethal disease has been a strategic target for cancer researchers. In recent years, important immunobiological aspects of the tumor have been revealed with the subsequent proposal of immune check point inhibitors to target these pathways. Clinically, unselected use of immune checkpoint inhibitors in gastric cancer has been deemed with failure; in contrast to the clear success of more recent studies reporting on the use of pembrolizumab in molecularly selected patients. This may illustrate that any future use of immune checkpoint inhibitors in gastric cancer has to be molecularly supported. This review provides a delicate dissection of the clinical and immunobiological considerations underlying the use of these agents in addition to a thorough review of the published clinical data of immune checkpoint inhibitors in gastric cancer.

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Citations

Mar 9, 2017·Clinical and Experimental Pharmacology & Physiology·Batoul FarranRaquel C Montenegro
Mar 6, 2016·Therapeutic Advances in Respiratory Disease·Omar Abdel-Rahman, Mona Fouad
Dec 5, 2017·Expert Review of Gastroenterology & Hepatology·Omar Abdel-Rahman
May 25, 2016·World Journal of Gastroenterology : WJG·Moon Kyung JooHoon Jai Chun
Dec 22, 2016·Immunotherapy·Mahmoud A AliOmar Abdel-Rahman
Jul 29, 2016·World Journal of Gastroenterology : WJG·Marwa MatboliOmar Abdel-Rahman
Jun 5, 2020·OncoTargets and Therapy·Shanshan NieHongwei Lu
May 20, 2016·Cancer Research·Mark T UhlikLaura E Benjamin

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