Immune checkpoints indoleamine 2,3-dioxygenase 1 and programmed death-ligand 1 in oral mucosal dysplasia.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Meri SieviläinenAhmed Al-Samadi

Abstract

Oral mucosal dysplasia is a histologic feature of potentially malignant disorders that is associated with the risk of transformation to carcinoma. Dysplastic cells use many strategies during their transformation to cancer, including escape from the immune mediated destruction. We hypothesized that adaptive immunity is inhibited by activation of distinct immune checkpoint molecules, such as indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1). We collected 63 oral dysplasia samples from 47 patients. Nine biopsies from alveolar mucosa were taken during wisdom teeth extractions were used as healthy controls. Tissue samples were stained and scored for IDO1 and PD-L1. Additionally, dysplasia grades and inflammatory cell infiltration were evaluated. Eight patients were followed up to 36 months to evaluate dysplasia progression, inflammation, and immune checkpoint molecules expression. Dysplastic epithelium had significantly lower IDO1 expression than that of healthy controls. PD-L1 positive cells in the lamina propria were mainly in dysplastic samples and seldom in healthy controls. Dysplasia grade was associated negatively with epithelium IDO1 and positively with IDO1 and PD-L1 expression in the lamina propria....Continue Reading

References

Jul 12, 2002·Arthritis Research·Joost J OppenheimPaul Plotz
Feb 3, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cory M RobinsonJoseph M Carlin
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoPaolo Puccetti
Jan 15, 2011·International Journal of Clinical Oncology·Toshiyuki Izumo
Feb 20, 2015·Molecular Cancer Therapeutics·Sandip Pravin Patel, Razelle Kurzrock
Mar 3, 2015·Frontiers in Immunology·Ursula Grohmann, Paolo Puccetti
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Jun 27, 2015·PloS One·Pin WuJian Huang
Jul 21, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S Warnakulasuriya, A Ariyawardana
Mar 17, 2016·Acta Oto-laryngologica·Miia SeppäläSanna Toppila-Salmi
Jul 3, 2017·Pathology Oncology Research : POR·Olga Stasikowska-KanickaMarian Danilewicz
Sep 9, 2017·JAMA : the Journal of the American Medical Association·Suzanne L Topalian
May 10, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Atsumu KouketsuHiroyuki Kumamoto

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Citations

Mar 9, 2020·Archives of Oral Biology·Rafaely Ferreira SeveroFernanda Nedel
Aug 22, 2021·Oral Diseases·Edward OdellPhilip Sloan

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