Immune checkpoints on innate lymphoid cells

The Journal of Experimental Medicine
Laura Chiossone, Eric Vivier

Abstract

In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti-PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice.

References

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Citations

Dec 10, 2019·The Journal of Experimental Medicine·Maryam GhaediFumio Takei
Dec 11, 2019·The Journal of Experimental Medicine·Thomas A WaldmannKevin C Conlon
Apr 27, 2020·British Journal of Pharmacology·F R MariottiL Moretta
Jun 20, 2019·Frontiers in Immunology·Silvia PesceEmanuela Marcenaro
Jul 30, 2019·Frontiers in Immunology·Jia XiongQingqing Wang
Nov 26, 2020·Cancers·Enrico MaggiFrancesco Annunziato
Mar 18, 2021·Molecular Aspects of Medicine·Claudia De PasqualeGuido Ferlazzo
Jun 3, 2021·International Journal of Molecular Sciences·Enrico MunariLorenzo Moretta
Jun 29, 2021·Molecular Aspects of Medicine·Cristina BottinoRoberta Castriconi
Jul 1, 2021·European Journal of Immunology·Xiaodong YuanCheng Sun

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