Jul 1, 1989

Immune complex mediated activation of the classical complement pathway

Behring Institute Mitteilungen
T Borsos


The activation of classical C pathway by immune complexes depends on the binding and activation of C1, the first component of C. The Ig in the complex must be of the right class and in the right configuration to accomplish the conversion of precursor (zymogen) C1s to C1s, the active enzyme, whose substrates are C4 and C2. The primary question discussed in this paper is evidence that indicates that epitope distribution and density is a major factor in controlling the configuration of antibodies which in turn controls the activation of bound C1. This evidence confirms earlier findings that binding of C1 is a necessary but not sufficient condition for activating C1.

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Mentioned in this Paper

Antigenic Specificity
Plasma Protein Binding Capacity
Complement C1q
Protein Conformation
Immune complex
Complement Pathway, Classical
Complement component C1
Cavia porcellus

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