Immune-complex trapping in the splenic ellipsoids of rainbow trout (Oncorhynchus mykiss)

Cell and Tissue Research
A EspenesT Landsverk

Abstract

Rainbow trout (Oncorhynchus mykiss), immunised with horseradish peroxidase, were given horseradish peroxidase intravenously, and the trapping of antigen in the spleen was followed 1, 24, and 48 h after injection. After 1 h, the localisation of horseradish peroxidase indicated that the antigen had been extensively trapped in the walls of the splenic ellipsoids. The colocalization of horseradish peroxidase with rainbow trout immunoglobulin M and complement factor 3 was shown with a double immunofluorescence technique and suggested that horseradish peroxidase was trapped in the form of immune complexes. After 24 and 48 h, very little horseradish peroxidase was detected in the ellipsoids, and horseradish peroxidase was mainly found in association with large cells with prominent cytoplasmic extensions. In non-immunized fish given horseradish peroxidase intravenously, antigen was not detected in ellipsoids. Thus, the observed difference between immunised and non-immunized trout suggests a specific role for the splenic ellipsoids in rapid immune-complex trapping and invites speculation on its significance in a secondary immune response.

References

Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G W Miller, V Nussenzweig
Jan 1, 1990·Developmental and Comparative Immunology·A ThuvanderN Lorenzen
Jul 1, 1989·Immunology Today·J G TewA K Szakal
Jun 1, 1986·Veterinary Immunology and Immunopathology·M J Irwin, S L Kaattari
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·J M MansonC Boyd
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·N BuyssensN Bourgeois
Dec 1, 1982·The American Journal of Anatomy·I Oláh, B Glick
Jun 1, 1981·The American Journal of Anatomy·J Blue, L Weiss
Mar 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·V B TurovetskiĭA A Kamenskiĭ
Jun 1, 1984·Immunology Today·B Glick, I Olah
Aug 1, 1981·Immunology Today·R G White

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Citations

Dec 18, 2013·Histochemistry and Cell Biology·Birte S SteinigerVitus Stachniss
Feb 13, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Randi SørbyGunilla Westermark
Jan 29, 2010·Developmental and Comparative Immunology·Holly L SaundersBrad G Magor
Nov 6, 2007·Fish & Shellfish Immunology·Shona K Whyte
May 17, 2005·Journal of Comparative Pathology·R SørbyT Landsverk
Nov 24, 2012·Molecular and Cellular Endocrinology·Marty Kwok-Shing Wong, Yoshio Takei
Oct 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A OulmoudenR Julien
Aug 2, 2020·Parasite Immunology·Mateusz KonczalMagdalena Chadzinska

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