PMID: 444313May 1, 1979Paper

Immune complexes in rheumatoid arthritis sera and synovial fluids: a comparison of three methods

Arthritis and Rheumatism
J T HallaR E Schrohenloher

Abstract

Sera and synovial fluids from 88 patients with rheumatoid arthritis were examined for circulating immune complexes by three assays: monoclonal rheumatoid factor radioimmunoassay, C1q binding assay, and Raji cell radioassay. Paired samples were available for 82 patients. Immune complexes were detected with high frequency in the synovial fluid by each assay (75% by the monoclonal rheumatoid factor radioimmunoassay, 95% by the C1q binding assay, and 61% by the Raji cell readioassay). In rheumatoid arthritis sera, immune complexes were detected with high frequency by the C1q binding assay (85%) and the monoclonal rheumatoid factor radioimmunoassay (70%) but infrequently by the Raji cell radioassay (26%). The presence of immune complexes in serum was most frequently accompanied by the presence of complexes in fluid, regardless of the method of detection; moreover, the levels of immune complexes in synovial fluid were generally higher than in paired serum. Further, the levels of immune complexes as measured by the C1q binding assay correlated with certain parameters of clinical activity, while the monoclonal rheumatoid factor radioimmunoassay and Raji cell radioassay correlated with extraarticular features (excluding nodules) of rheu...Continue Reading

References

Jan 1, 1976·The Journal of Clinical Investigation·A N TheofilopoulosF J Dixon
May 1, 1977·The Journal of Clinical Investigation·A Gabriel, V Agnello
May 1, 1979·Arthritis and Rheumatism·J T HallaR E Schrohenloher
Jun 13, 1975·Annals of the New York Academy of Sciences·R J Winchester
Dec 1, 1975·Immunochemistry·J D ConradieR M Stroud
Jun 13, 1975·Annals of the New York Academy of Sciences·D A GordonI Broder
May 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·H Metzger
Dec 1, 1956·The American Journal of Medicine·C M PLOTZ, J M SINGER
Jan 1, 1961·The Journal of Clinical Investigation·H G KUNKELT B TOMASI
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN

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Citations

Jan 1, 1984·Rheumatology International·U LatzkaC Steffen
Jan 1, 1988·Springer Seminars in Immunopathology·M MannikE H Sasso
Jun 1, 1984·Clinical Rheumatology·A Pines, I Ben-Bassat
Sep 24, 1987·Journal of Immunological Methods·U AntesM Loos
Feb 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peter A NigrovicDavid M Lee
Dec 1, 1981·Annals of the Rheumatic Diseases·J HightonT Gibson
Jan 1, 1985·Scandinavian Journal of Rheumatology·E KappelgaardT Ingemann-Hansen
Dec 30, 1983·The American Journal of Medicine·I A Jaffe
May 1, 1981·The American Journal of Medicine·R D Inman, N K Day
Aug 1, 1985·Clinical Immunology and Immunopathology·R S PanushR A Yonker
Dec 19, 2018·Immunology·Maran L SprouseHsin-Jung Joyce Wu
Jul 1, 1989·Annals of the Rheumatic Diseases·H Gonzalez-BuriticaR A Turner
Mar 8, 2019·JCI Insight·Margaret H Chang, Peter A Nigrovic
Apr 6, 2019·Frontiers in Immunology·Krysta M FelixHsin-Jung Joyce Wu
Jan 20, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas A BatesHsin-Jung Joyce Wu

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