Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth

Oncotarget
Alok RanjanSanjay K Srivastava

Abstract

Glioblastoma is the most common and lethal brain tumor associated with only 12% median survival rate of patients. Despite the development of advanced surgical, radiation or use of combinations of anti-cancer drugs, treatment for glioblastoma patients is still a challenge. The major contributing factor in glioblastoma progression and resistive nature is its ability to evade the immune surveillance. Hence, modulating the immune system in glioblastoma tumors could be an important strategy for anticancer therapeutics. Penfluridol, an antipsychotic drug has been shown to have anti-cancer properties in our recently published studies. The present study evaluates the immune response of penfluridol in glioblastoma tumors. Our results demonstrated that penfluridol treatment significantly suppressed glioblastoma tumor growth. Our current results demonstrated about 72% suppression of myeloid derived suppressor cells (MDSCs) with penfluridol treatment in mouse bearing U87MG glioblastoma tumors. MDSCs are known to increase regulatory T cells (Treg), which are immunosuppressive in nature and suppresses M1 macrophages that are tumor suppressive in nature. Our results also showed suppression of regulatory T cells as well as elevation of M1 macr...Continue Reading

References

May 1, 1979·The Journal of Pharmacy and Pharmacology·E J ConeC W Gorodetzky
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jun 28, 2006·Theoretical Biology & Medical Modelling·Richmond T Prehn
May 10, 2008·Seminars in Cancer Biology·Antonio SicaAlberto Mantovani
May 24, 2008·Cell Death and Differentiation·L Ricci-VitianiR De Maria
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne Ostrand-Rosenberg, Pratima Sinha
May 26, 2009·Immunity·Maria A Curotto de Lafaille, Juan J Lafaille
Jan 12, 2010·The Journal of Allergy and Clinical Immunology·Theresa L Whiteside
Jan 1, 2009·Molecular and Cellular Pharmacology·Elizabeth R RayburnRuiwen Zhang
May 24, 2012·Expert Review of Molecular Diagnostics·Hui ZongPeter Canoll
Sep 29, 2012·Immunological Investigations·Gary Kohanbash, Hideho Okada
May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Shihong ChenMoses Sing Sum Chow
Sep 12, 2014·British Journal of Cancer·J NaidooJ D Wolchok
Nov 19, 2014·Critical Reviews in Immunology·Josefin ZschalerJuergen Arnhold
Aug 6, 2015·Breast Cancer Research : BCR·Sofia SousaJorma A Määttä
Sep 25, 2015·Scientific Reports·Ang YuanPan-Chyr Yang
Nov 20, 2015·American Journal of Respiratory and Critical Care Medicine·Emma M ConwayKevin L Bennewith
Feb 10, 2016·Trends in Immunology·Vinit KumarDmitry I Gabrilovich
Mar 22, 2016·NPJ Breast Cancer·Carly Bess WilliamsAdam C Soloff
Mar 27, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masaki MandaiIkuo Konishi
Nov 24, 2016·Journal of Clinical Pathology·Bruno MärklGerhard Schenkirsch
Apr 6, 2017·Oncotarget·Alok Ranjan, Sanjay K Srivastava

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Citations

Mar 27, 2019·Scientific Reports·Nehal GuptaSanjay K Srivastava
Sep 6, 2020·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Özlem ÖzdemirHasan Turkez
Jan 26, 2020·International Journal of Molecular Sciences·Suyash SrivastavaConstantinos M Mikelis
Oct 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nguyen Minh Tuan, Chang Hoon Lee
May 30, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ning-Ning WangXiao-Feng Lv
Oct 17, 2019·Seminars in Cancer Biology·Vikram ShawSanjay K Srivastava
May 22, 2020·Seminars in Cancer Biology·Itishree KaushikSanjay K Srivastava
Jun 3, 2021·International Journal of Molecular Sciences·Nehal GuptaSanjay K Srivastava
Oct 8, 2020·Molecular Therapy Oncolytics·Sharavan Ramachandran, Sanjay K Srivastava

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Methods Mentioned

BETA
fluorescence cytometry
florescence cytometry
ELISA
FACS

Software Mentioned

Accuri C6 flow cytometer
Prism
GraphPad

Related Concepts

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