Immune Correlates of Protection Against Human Cytomegalovirus Acquisition, Replication, and Disease.

The Journal of Infectious Diseases
Cody S NelsonSallie R Permar

Abstract

Human cytomegalovirus (HCMV) is the most common infectious cause of infant birth defects and an etiology of significant morbidity and mortality in solid organ and hematopoietic stem cell transplant recipients. There is tremendous interest in developing a vaccine or immunotherapeutic to reduce the burden of HCMV-associated disease, yet after nearly a half-century of research and development in this field we remain without such an intervention. Defining immune correlates of protection is a process that enables targeted vaccine/immunotherapeutic discovery and informed evaluation of clinical performance. Outcomes in the HCMV field have previously been measured against a variety of clinical end points, including virus acquisition, systemic replication, and progression to disease. Herein we review immune correlates of protection against each of these end points in turn, showing that control of HCMV likely depends on a combination of innate immune factors, antibodies, and T-cell responses. Furthermore, protective immune responses are heterogeneous, with no single immune parameter predicting protection against all clinical outcomes and stages of HCMV infection. A detailed understanding of protective immune responses for a given clinica...Continue Reading

References

Oct 22, 1987·The New England Journal of Medicine·D R SnydmanA S Levey
Aug 1, 1987·Archives of Disease in Childhood·C S PeckhamK S Chin
May 8, 1980·The New England Journal of Medicine·S StagnoC A Alford
May 1, 1984·Human Pathology·D MyersonJ K McDougall
Nov 1, 1996·Placenta·P F Whitelaw, B A Croy
May 20, 1999·The Journal of Clinical Investigation·J DéchanetJ F Moreau
Mar 8, 2000·Virology·K M LockridgeP A Barry
Jul 24, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·M BoeckhJ A Zaia
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanCarlos Paya
Apr 3, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D N ForthalG Landucci
Aug 20, 2002·The Journal of General Virology·P J Klasse, Q J Sattentau
Mar 14, 2003·Journal of Virology·Isidore RigoutsosThomas Shenk
May 28, 2003·Journal of Virology·Scott G HansenScott W Wong
Nov 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eain MurphyThomas E Shenk
Jan 30, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maria Grazia Revello, Giuseppe Gerna
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenwei TuDavid B Lewis
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David MasopustLeo Lefrançois
Jun 3, 2004·Human Immunology·Laila E GamadiaIneke J M ten Berge
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Maria C SilvaThomas Shenk
Mar 30, 2005·The Journal of Experimental Medicine·Torsten BundeFlorian Kern
Sep 9, 2005·The Journal of Experimental Medicine·Andrew W SylwesterLouis J Picker
Oct 13, 2005·European Journal of Immunology·Adam W BingamanDonna L Farber
Dec 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Dai Wang, Thomas Shenk
Dec 20, 2005·The Journal of Infectious Diseases·Maria Grazia RevelloGiuseppe Gerna
Mar 14, 2007·The Journal of Experimental Medicine·Claire DunnMala K Maini
Jul 4, 2007·BMC Infectious Diseases·Fernando A B ColugnatiMichael J Cannon
Oct 30, 2007·Trends in Immunology·Vitaly V Ganusov, Rob J De Boer
Jan 15, 2008·Medical Microbiology and Immunology·Colin Powers, Klaus Früh
Jan 29, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christophe Legendre, Manuel Pascual

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

© 2021 Meta ULC. All rights reserved