Immune dependence of schistosomicidal chemotherapy: an ultrastructural study of Schistosoma mansoni adult worms exposed to praziquantel and immune serum in vivo

Parasite Immunology
J ModhaD J McLaren

Abstract

This study examines the immune-dependence of praziquantel (PZQ) for the treatment of Schistosomiasis mansoni in mice. We have shown elsewhere from worm recovery data that the efficacy of PZQ is significantly enhanced when mice are treated concomitantly with antisera raised against antigens released from adult schistosomes, even though such antisera show no intrinsic helminthotoxic activity (Doenhoff et al. 1987, Doenhoff, Modha & Lambertucci 1988). Moreover, indirect immunofluorescence assays have shown that male worms exposed to the dual treatment regime in vivo bind antiserum to their dorsal surfaces in a pattern that seems to follow the outline of the dorsal tubercles. Scanning and transmission electron microscopy have now been used to further define the features of damage inflicted upon worms through exposure to antiserum alone, drug alone, or the two treatments in combination. Such investigations revealed that the antiserum induces a classical membrane repair process in worms of both sexes, but little other damage. PZQ causes the formation of spherical protuberances on the dorsal tubercles of male worms, while the dual treatment regime induces both kinds of damage in male schistosomes, but with much enhanced severity. The ...Continue Reading

References

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Citations

Mar 4, 2009·Parasitology Research·Rashad Abdul-GhaniAzza Hassan
Oct 1, 1990·Parasitology Today·G F Mitchell
Jan 1, 1991·Parasitology Today·M J DoenhoffD J McLaren
Jan 1, 1996·Parasitology Today·C A RedmanR J Martin
Mar 10, 2004·Micron : the International Research and Review Journal for Microscopy·David W Halton
Feb 1, 1997·General Pharmacology·G J FrayhaJ Savel
Jun 1, 1991·Journal of Helminthology·A H Awad, A J Probert
Jul 16, 2013·Infectious Diseases of Poverty·Humphrey D MazigoDavid W Dunne
Jan 1, 1992·Parasitology
Jul 12, 2008·Acta Tropica·N Katz, P M Z Coelho
Mar 17, 2015·PLoS Neglected Tropical Diseases·Natalie ReimersGabriele Schramm
May 4, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Caliandra Maria Bezerra Luna LimaMargareth de Fátima Formiga Melo Diniz
May 1, 1997·Memórias do Instituto Oswaldo Cruz·L R BarthV Rodrigues
Nov 23, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Renata Eliane de AvilaJosé Roberto Lambertucci
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·Jürg UtzingerBurton H Singer
Jan 1, 1992·Parasitology·P G FallonM J Doenhoff

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