Immune Desertic Landscapes in Hepatocellular Carcinoma Shaped by β-Catenin Activation

Cancer Discovery
Pedro BerraondoIgnacio Melero

Abstract

About one third of cases of hepatocellular carcinoma (HCC) show gain-of-function mutations of CTNNB1 (β-catenin) that correlate with sparse intratumoral T-cell content, as observed previously in an ample spectrum of malignancies, and there is mounting preliminary evidence that such HCC cases are refractory to treatment with PD-1 checkpoint inhibitors. Elegant hepatocarcinogenesis experiments by in vivo gene transfer to mouse hepatocytes show that coexpression of active forms of β-catenin result in poor T-cell infiltrates, faster progression in immunocompetent hosts, and unresponsiveness to immunotherapy with checkpoint inhibitors.See related article by Ruiz de Galarreta et al., p. 1124.

References

Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
May 15, 2015·Nature·Stefani SprangerThomas F Gajewski
Dec 10, 2015·Cancer Discovery·Weiyi PengPatrick Hwu
Jan 20, 2017·Nature·Daniel S Chen, Ira Mellman
Jan 13, 2018·Nature Reviews. Cancer·Stefani Spranger, Thomas F Gajewski
Oct 31, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James J HardingGhassan K Abou-Alfa
Jan 13, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jason J LukeThomas F Gajewski

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Citations

Apr 15, 2021·Nature Reviews. Gastroenterology & Hepatology·Bruno SangroIgnacio Melero
Jun 3, 2021·Cancers·Carla GiacobinoValentina Cauda
Jul 3, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yan HuangJingyuan Sun
Apr 7, 2021·Journal of the National Cancer Institute·Elena FountzilasApostolia-Maria Tsimberidou

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