PMID: 8605695Mar 1, 1996Paper

Immune dysfunction in Down's syndrome: primary immune deficiency or early senescence of the immune system?

Clinical Immunology and Immunopathology
E Cuadrado, M J Barrena

Abstract

Multiple immunologic disturbances are commonly observed in individuals with Down's syndrome including abnormal proportions of peripheral blood lymphoid subsets, cellular dysfunction, and autoimmune phenomena. However, a majority of the individuals with this syndrome do not show clear features of immunological disease. Many of these immunological alterations are age-related changes and can be enclosed in the spectrum of multiple signs of early senescence characteristic of Down's syndrome.

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