Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis

Journal of Internal Medicine
C SlocumC A Genco

Abstract

Cardiovascular disease is an inflammatory disorder characterized by the progressive formation of plaque in coronary arteries, termed atherosclerosis. It is a multifactorial disease that is one of the leading causes of death worldwide. Although a number of risk factors have been associated with disease progression, the underlying inflammatory mechanisms contributing to atherosclerosis remain to be fully delineated. Within the last decade, the potential role for infection in inflammatory plaque progression has received considerable interest. Microbial pathogens associated with periodontal disease have been of particular interest due to the high levels of bacteremia that are observed after routine dental procedures and every day oral activities, such as tooth brushing. Here, we explore the potential mechanisms that may explain how periodontal pathogens either directly or indirectly elicit immune dysregulation and consequently progressive inflammation manifested as atherosclerosis. Periodontal pathogens have been shown to contribute directly to atherosclerosis by disrupting endothelial cell function, one of the earliest indicators of cardiovascular disease. Oral infection is thought to indirectly induce elevated production of infla...Continue Reading

References

Jul 1, 1976·Postgraduate Medical Journal·M L Armstrong
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C C KuoJ T Grayston
Apr 1, 1996·The Journal of Infectious Diseases·S M WeissJ Schachter
Oct 1, 1996·Journal of Periodontology·R J Genco
Oct 1, 1996·Journal of Periodontology·J BeckS Offenbacher
Jan 1, 1997·Frontiers in Bioscience : a Journal and Virtual Library·C A Feghali, T M Wright
Apr 4, 1998·Journal of Periodontology·R C OliverH Löe
Apr 10, 1999·Journal of Cardiovascular Risk·H I MorrisonG W Taylor
Feb 24, 2000·Journal of Periodontal Research·S OffenbacherJ D Beck
Nov 4, 2000·Journal of Periodontology·V I HaraszthyR J Genco
Dec 2, 2000·Journal of Clinical Microbiology·B FarsakL Tokgözoğlu
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·S F AmerisoG E Sevlever
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·Ingrid GlurichErnesto De Nardin
May 24, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Salomon AmarJoseph A Vita
Sep 18, 2003·JAMA : the Journal of the American Medical Association·Christopher M O'ConnorUNKNOWN Investigators in the WIZARD Study
Oct 29, 2003·Microbial Pathogenesis·Mingshan QiHoward K Kuramitsu
Jan 31, 2004·Seminars in Immunology·Kiyoshi Takeda, Shizuo Akira
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kathrin S MichelsenMoshe Arditi
Jan 7, 2005·Journal of Clinical Microbiology·Margareta M Ieven, Vicky Y Hoymans
Jan 22, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Emil V KozarovAnn Progulske-Fox
Feb 22, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Céline Pujol, James B Bliska
Apr 22, 2005·The New England Journal of Medicine·J Thomas GraystonUNKNOWN ACES Investigators
Apr 22, 2005·The New England Journal of Medicine·Christopher P CannonUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators
Jun 1, 2005·Pharmacology & Therapeutics·Sharon K Krueger, David E Williams
Jun 25, 2005·American Heart Journal·Gerald SeinostErnst Pilger
Sep 27, 2005·Atherosclerosis·Sinead ToomeyOrina Belton
Sep 27, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mehmet KaplanMahmut Murat Demirtas
Nov 10, 2005·The Journal of Pathology·I E AdamopoulosN A Athanasou
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
Jan 26, 2006·Journal of Dental Research·F C GibsonC A Genco
Mar 15, 2006·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN ASTEROID Investigators
May 9, 2006·Journal of Clinical Periodontology·Lone FornerPalle Holmstrup
Jun 10, 2006·Circulation Research·Chieko MineoPhilip W Shaul
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Dec 23, 2006·Nature Reviews. Immunology·Sanjeev Mariathasan, Denise M Monack
Mar 17, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Pirkko J PussinenVeikko Salomaa
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min WangGeorge Hajishengallis

❮ Previous
Next ❯

Citations

Oct 18, 2016·Scientific Reports·Chung-Jung ChiuAllen Taylor
Aug 2, 2017·Periodontology 2000·Jeffrey L EbersoleOctavio A Gonzalez
May 16, 2018·International Journal of Oral Science·Peng XianLiao Ga
Aug 4, 2018·European Journal of Preventive Cardiology·Hong-Hao Sun, Feng Tian
Feb 17, 2019·European Heart Journal·Stefano MasiJohn Deanfield
Jul 6, 2019·Coronary Artery Disease·Lin LiuYingqing Feng
Apr 17, 2020·Postgraduate Medicine·Hsin-Hung ChenChia-Hung Kao
Aug 12, 2017·Journal of Clinical Periodontology·Prem K SreenivasanDaniel H Fine
Nov 8, 2017·Current Atherosclerosis Reports·James A HamiltonThomas Van Dyke
Sep 7, 2019·Journal of Oral Microbiology·Yaohua YangJirong Long
Dec 15, 2019·Scientific Reports·Beatrice KennedyTove Fall
Sep 16, 2017·Frontiers in Immunology·Ioana MozosAtanas G Atanasov
Dec 14, 2018·Biomedicines·Hiba MohammedVincenzo Rocchetti
Feb 6, 2020·Aging Clinical and Experimental Research·Lei QiLei Zhang
Jul 24, 2020·International Journal of Environmental Research and Public Health·Soo Hwan ByunSeok Jin Hong
Nov 28, 2020·Dermatology and Therapy·Kirsty J L Wark, Geoffrey D Cains
Jul 31, 2020·Cancer Prevention Research·Chun-Han LoMingyang Song
Jan 26, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Peizeng JiaQian Zhang
Feb 11, 2021·Cells·Natalia KurilenkoEkaterina K Koltsova
Nov 23, 2020·Environmental Science and Pollution Research International·Ehsan AhmadifarAliakbar Hedayati
Dec 6, 2020·Cancer Prevention Research·Xiaotao ZhangCarrie R Daniel
Jun 3, 2021·International Journal of Molecular Sciences·Adelina S PlachokovaNiels P Riksen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.